Kinase insert domain receptor

Kinase insert domain receptor (a type III receptor tyrosine kinase)
Rendering of 1VR2
Available structures PDB 1VR2, 1Y6A, 1Y6B, 1YWN, 2OH4, 2P2H, 2P2I, 2QU5, 2QU6, 2RL5, 2X1W, 2X1X, 3B8Q, 3B8R, 3BE2, 3C7Q, 3CJF, 3CJG, 3CP9, 3CPB, 3CPC, 3DTW, 3EFL, 3EWH, 3KVQ
Identifiers
Symbols	KDR; CD309; FLK1; VEGFR; VEGFR2
External IDs	OMIM: 191306 MGI: 96683 HomoloGene: 55639 GeneCards: KDR Gene
EC number	2.7.10.1
Gene Ontology Molecular function • nucleotide binding • transmembrane receptor protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • receptor activity • vascular endothelial growth factor receptor activity • integrin binding • protein binding • ATP binding • growth factor binding • Hsp90 protein binding Cellular component • plasma membrane • integral to plasma membrane Biological process • angiogenesis • positive regulation of endothelial cell proliferation • transmembrane receptor protein tyrosine kinase signaling pathway • multicellular organismal development • positive regulation of cell proliferation • regulation of cell shape • positive regulation of endothelial cell migration • cell differentiation • positive regulation of cell migration • interspecies interaction between organisms • vascular endothelial growth factor receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • positive regulation of positive chemotaxis • positive regulation of focal adhesion assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3791	16542
Ensembl	ENSG00000128052	ENSMUSG00000062960
UniProt	P35968	Q3UQZ6
RefSeq (mRNA)	NM_002253.2	NM_010612.2
RefSeq (protein)	NP_002244.1	NP_034742.2
Location (UCSC)	Chr 4: 55.94 – 55.99 Mb	Chr 5: 76.33 – 76.37 Mb
PubMed search	[1]	[2]

Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).

Interactions

Kinase insert domain receptor has been shown to interact with SHC2, Annexin A5 and SHC1.

See also

• Cluster of differentiation
• VEGF receptors

Further reading

• Holmes K, Roberts OL, Thomas AM, Cross MJ. (Oct 2007). "Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.". Cell Signal. 19 (10): 2003–2012. doi:10.1016/j.cellsig.2007.05.013. PMID 17658244. 
• Petrova TV, Makinen T, Alitalo K (1999). "Signaling via vascular endothelial growth factor receptors.". Exp. Cell Res. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917. 
• Sato Y, Kanno S, Oda N, et al. (2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction.". Ann. N. Y. Acad. Sci. 902 (1): 201–5; discussion 205–7. doi:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839. 
• Zachary I, Gliki G (2001). "Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.". Cardiovasc. Res. 49 (3): 568–81. doi:10.1016/S0008-6363(00)00268-6. PMID 11166270. 
• Vené R, Benelli R, Noonan DM, Albini A (2001). "HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis.". Clin. Exp. Metastasis 18 (7): 533–8. doi:10.1023/A:1011991906685. PMID 11688957. 
• Lenton K (2003). "VEGFR-2 (KDR/Flk-1).". J. Biol. Regul. Homeost. Agents 16 (3): 227–32. PMID 12456025. 
• Matsumoto T, Mugishima H (2006). "Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis.". J. Atheroscler. Thromb. 13 (3): 130–5. doi:10.5551/jat.13.130. PMID 16835467. 

External links

• MeSH Kinase+insert+domain+receptor

This article incorporates text from the United States National Library of Medicine, which is in the public domain.