Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly. The kindling model was first proposed in the late 1960s by Goddard and colleagues. Although kindling is a widely used model, its applicability to human epilepsy is controversial.
The word kindling is a metaphor: the increase in response to small stimuli is similar to the way small burning twigs can produce a large fire. It is used by scientists to study the effects of repeated seizures on the brain. A seizure may increase the likelihood that more seizures will occur; an old saying in epilepsy research is "seizures beget seizures". Repeated stimulation "lowers the threshold" for more seizures to occur.
The brains of experimental animals are repeatedly stimulated, usually with electricity, to induce the seizures. Chemicals may also be used to induce seizures. The seizure that occurs after the first such electrical stimulation lasts a short time and is accompanied by a small amount of behavioral effects compared with seizures that result from repeated stimulations. With further seizures, the accompanying behavior intensifies, for example progressing from freezing in early stimulations to convulsions in later ones. The lengthening of duration and intensification of behavioral accompaniment eventually reaches a plateau after repeated stimulation. Even if animals are left unstimulated for as long as 12 weeks, the effect remains; the response to stimulation remains higher than it had been before.
It has been reported that repeated seizure stimulation can result in spontaneous seizures, but studies have had conflicting findings on this question. In humans, some seizure disorders come to an end by themselves even after large numbers of seizures. However, in both human epilepsy and in some animal models, evidence suggests that a process like that found in kindling does occur.
Already in the 1950s and 1960s, numerous authors recognized the seizure-inducing potential of focal stimulation. Here, Delgado and Sevillano demonstrated that repeated low-intensity stimuli to the hippocampus could lead to progressive increase of electrically evoked seizure activity. Yet, it was not until the late 1960s that Graham Goddard recognized the potential importance of this phenomenon and coined the term 'kindling'. Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. The publication of these results opened an completely new niche for epilepsy research and has stimulated a significant amount of studies on the subject of kindling and its relevance to human epilepsy
- Kindling (substance withdrawal)
- Racine Stages (a method by which seizure severity is quantified in animal models of epilepsy)
- Bertram E (2007). "The relevance of kindling for human epilepsy". Epilepsia 48 (Supplement 2): 65–74. doi:10.1111/j.1528-1167.2007.01068.x. PMID 17571354.
- Sato M (2008). "Kindling: An experimental model of epilepsy" (PDF). Psychiatry and Clinical Neurosciences 36 (4): 440–441. doi:10.1111/j.1440-1819.1982.tb03123.x.
- Abel MS, McCandless DW (1992). "The kindling model of epilepsy". In Adams RN, Baker GB, Baker JM, Bateson AN, Boisvert DPJ, Boulton AA et al. Neuromethods: Animal Models of Neurological Disease. Totowa, NJ: Humana Press. pp. 153–155. ISBN 0-89603-211-6.
- PK Sahoo, KI Mathai, GV Ramdas, MN Swamy (2007). "The pathophysiology of post traumatic epilepsy" (PDF). Indian Journal of Neurotrauma 4 (1): 11–14. doi:10.1016/s0973-0508(07)80004-9. Temkin NR, Jarell AD, Anderson GD (2001). "Antiepileptogenic agents: how close are we?". Drugs 61 (8): 1045–55. doi:10.2165/00003495-200161080-00002. PMID 11465868.
- Morimoto K, Fahnestock M, Racine RJ (May 2004). "Kindling and status epilepticus models of epilepsy: Rewiring the brain". Prog. Neurobiol. 73 (1): 1–60. doi:10.1016/j.pneurobio.2004.03.009. PMID 15193778.
- McNamara JO, Byrne MC, Dasheiff RM, JG Fitz (1980). "The Kindling Model of Epilepsy; a Review". Progress in Neurobiology 15 (2): 139–59. doi:10.1016/0301-0082(80)90006-4. PMID 6109361.
- Delgado JMR and Sevillano M (1961). "Evolution of repeated hippocampal seizures in the cat". Electroenceph. clin. Neurophys 13 (2): 722–733. doi:10.1016/0013-4694(61)90104-3.
- Goddard GV (1967). "Development of epileptic seizures through brain stimulation at low intensity". Nature 214: 1020–1. doi:10.1038/2141020a0. PMID 6055396.
- Goddard GV, McIntyre DC, Leech CK (1969). "A permanent change in brain function resulting from daily electrical stimulation". Exp Neurol 25 (3): 295–330. doi:10.1016/0014-4886(69)90128-9. PMID 4981856.