Kininogens are proteins that are defined by their role as precursors for kinin, but that also can have additional roles.
The two main types are:
- High-molecular-weight kininogen, which is produced by the liver together with prekallikrein. It acts mainly as a cofactor on coagulation and inflammation, and has no intrinsic catalytic activity. These high molecular weight kininogens are cleaved into bradykinin and kallidin by tissue and plasma kallikreins.
- Low-molecular-weight kininogen, which is produced locally by numerous tissues, and secreted together with tissue kallikrein.
They are both spliced from the same precursor.
A third type, T-kininogen, is found in rats but not humans.
Closely related proteins include cystatin.
- Kininogens at the US National Library of Medicine Medical Subject Headings (MeSH)
- The kinin-forming system at sav.sk
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