Kininogen 1

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Kininogen 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KNG1 ; BDK; BK; KNG
External IDs OMIM612358 MGI3027157 HomoloGene88343 GeneCards: KNG1 Gene
RNA expression pattern
PBB GE KNG1 206054 at tn.png
PBB GE KNG1 217512 at tn.png
More reference expression data
Species Human Mouse
Entrez 3827 16644
Ensembl ENSG00000113889 ENSMUSG00000022875
UniProt P01042 O08677
RefSeq (mRNA) NM_000893 NM_001102411
RefSeq (protein) NP_000884 NP_001095881
Location (UCSC) Chr 3:
186.44 – 186.46 Mb
Chr 16:
23.06 – 23.08 Mb
PubMed search [1] [2]

Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor, is a protein that in humans is encoded by the KNG1 gene.[1]


The KNG1 gene uses alternative splicing to generate two different proteins- high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[1]

Kininogen-1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.

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