Kirtlebridge is a village in Dumfries and Galloway, southern Scotland. It is located 8 kilometres (5.0 mi) north-east of Annan, 5 kilometres (3.1 mi) north-west of Kirkpatrick-Fleming, and 1.5 kilometres (0.93 mi) south of Eaglesfield. The village is located where the A74(M) motorway and the West Coast Main Line railway cross the Kirtle Water.
Kirtlebridge railway station on the main line formerly served the village, and a nearby junction marked the start of the Solway Junction Railway to Annan. The Kirtlebridge rail crash occurred at the station on 2 October 1872, and resulted in 12 deaths.
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