In Lennon and Ono's joint 1980 interview with Playboy, Ono said:
John is saying in his song [Starting Over], OK, we had the energy in the Sixties, in the Seventies we separated, but let's start over in the Eighties. He's reaching out to me, the woman. Reaching out after all that's happened, over the battlefield of dead families, is more difficult this time around. On the other side of the record is my song, "Kiss Kiss Kiss," which is the other side of the same question. There is the sound of a woman coming to a climax on it, and she is crying out to be held, to be touched. It will be controversial, because people still feel it's less natural to hear the sounds of a woman's lovemaking than, say, the sound of a Concorde, killing the atmosphere and polluting nature. Altogether, both sides are a prayer to change the Eighties.
In 2002, following the success of "Open Your Box", the track was remixed by Superchumbo and released as a single. It reached #20 on the US dance charts.
In 2005, Detroit group The Dirtbombs included their cover of "Kiss, Kiss, Kiss" on their album If You Don't Already Have a Look. Most recently, the track was remixed by Peaches for the Yes, I'm a Witch album.