Klamath Agency was an Indian agency for the Klamath Indian Reservation established May 12, 1866, on the shore of Agency Lake. The current site of the former agency is 3 miles (5 km) north of that location. The Klamath Reservation was terminated in 1961, but the community at Klamath Agency still exists. Klamath Agency post office was established in 1878 and ran until 1965, when the mail was instead routed to Chiloquin.
In 1945, Ray Enouf Field was dedicated at the agency. The airfield was named in honor of the only Klamath Indian to die in World War II. Raymond L. Enouf was a Marine private first class, who was killed while acting as a medic in the front lines during the Battle of Iwo Jima.