Klaus-Peter Lesch

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Klaus-Peter Lesch is a clinical psychiatrist who has been investigating the neurobiological foundation of personality traits.

Klaus-Peter Lesch 2014

[1] His 1996 paper[2] on the association between the 5-HTTLPR polymorphism in the serotonin transporter gene and the personality trait neuroticism has been highly cited and was one of the first papers in personality genetics.

He is professor at the University of Würzburg. Among his coauthors has been Peter Riederer.

Important Publications[edit]

  • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1532
  • Canli T, Lesch KP (2007) Long story short: the serotonin transporter in emotion regulation and social cognition. Nature Neurosci 10:1103-1109
  • Murphy DL, Lesch KP (2008) Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci 9:85-96
  • Lesch KP, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, Romanos M, Shoichet S, Dempfle A, Heine M, Boreatti-Hümmer A, Walitza S, Romanos J, Gross-Lesch S, Zerlaut H, Allolio B, Heinzel S, Fassnacht M, Fallgatter A, Wultsch T, Schäfer H, Warnke A, Reif A, Ropers HH, Ullmann R (2011) Genome-wide copy number variation analysis in ADHD: association with neuropeptide Y gene dosage in an extended pedigree. Mol Psychiatry 16:491-503
  • Lesch KP, Waider J (2012) Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders. Neuron 76:175-191



  1. ^ "Interview with Prof. Dr. K.P. Lesch". in-cites. 
  2. ^ Klaus-Peter Lesch, D. Bengel, A. Heils, S. Z. Sabol, B. D. Greenberg, S. Petri, J. Benjamin, C. R. Muller, D. H. Hamer & D. L. Murphy (November 1996). "Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region". Science 274 (5292): 1527–1521. doi:10.1126/science.274.5292.1527. PMID 8929413.