|Jmol-3D images||Image 1|
|Molar mass||142.11 g/mol|
|Melting point||152 to 155 °C (306 to 311 °F; 425 to 428 K)|
|Solubility in water||Slight|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
Kojic acid is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji. Kojic acid is a by-product in the fermentation process of malting rice, for use in the manufacturing of sake, the Japanese rice wine. It is a mild inhibitor of the formation of pigment in plant and animal tissues, and is used in food and cosmetics to preserve or change colors of substances. It forms a bright red complex with ferric ions.
13C-Labeling studies have revealed at least two pathways to kojic acid. In the usual route, dehydratase enzymes convert glucose to kojic acid. Pentoses are also viable precursors in which case dihydroxyacetone is invoked as an intermediate.
Kojic acid may be used on cut fruits to prevent oxidative browning, in seafood to preserve pink and red colors, and in cosmetics to lighten skin. As an example of the latter, it is used to treat skin diseases like melasma. Kojic acid also has antibacterial and antifungal properties.
- Bjerrum, J., et al. Stability Constants, Chemical Society, London, 1958.
- R. Bentley, "From miso, sake and shoyu to cosmetics: a century of science for kojic acid", Nat. Prod. Rep. 2006, 23, 1046-1062.
- Yabuta T (1924). "The constitution of kojic acid, a gamma-pyrone derivative formed by Aspergillus oryzae from carbohydrates". Journal of the Chemical Society 125: 575–587. doi:10.1039/ct9242500575.
- Kojic acid and enzymatic browning
- Melasma, American Academy of Dermatology