Krüppel means, literally, "cripple" in German, named for the crippled appearance of mutant larva. Krüppel regulates the expression of several other gap genes.
See also Kruppel-like factors which have been recently investigated in the heart but are well characterized for their role in carcinogenesis.
- Diagram at Davidson College - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Krüppel (in blue) Hairy (green) and Giant (red).
- Kruppel protein, Drosophila at the US National Library of Medicine Medical Subject Headings (MeSH)
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