Krüppel
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Krüppel is a gap gene originally described in Drosophila melanogaster, which encodes a zinc finger transcription factor with four tandemly repeated zinc finger domains.[1]
Krüppel means, literally, "cripple" in German, named for the crippled appearance of mutant larva. Krüppel regulates the expression of several other gap genes.[2]
See also Kruppel-like factors which have been recently investigated in the heart but are well characterized for their role in carcinogenesis.
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- Diagram at Davidson College - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Krüppel (in blue) Hairy (green) and Giant (red).
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