Kyriacos A. Athanasiou

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Kyriacos A. Athanasiou (born August 1, 1960) is a renowned bioengineer who has contributed significantly to both academic advancements as well as high-technology industries. He is currently a Distinguished Professor at the University of California, Davis where he also serves as the Chair of the Biomedical Engineering department. Before he joined the University of California in 2009, he was the Karl F. Hasselmann Professor at Rice University. He has published hundreds of scientific articles detailing structure-function relationships and tissue engineering approaches for articular cartilage, the knee meniscus, and the temporomandibular joint.

Biography[edit]

Early life and education[edit]

Athanasiou was born in Larnaca, Cyprus on August 1, 1960. He went to Sotir Elementary School and St. George High School. In 1978, he graduated valedictorian from high school and then joined the army for 26 months as part of his mandatory military duty. During that time, he trained at an infantry cadet school eventually becoming a second lieutenant. In August 1980, he came to the United States to attend college. He spent his first year at Brescia College in Owensboro, Kentucky. He then moved with relatives in Long Island, New York.

Athanasiou received his Bachelor's degree in Mechanical Engineering from New York Institute of Technology at Old Westbury in 1984. He obtained his Masters degree from Columbia University in 1985, his Masters of Philosophy from Columbia University in 1987, and his Doctor of Philosophy degree from Columbia University in 1989.

Academic[edit]

Kyriacos Athanasiou has established one of the most recognized research groups in bioengineering, specializing in the cartilages of the musculoskeletal system. Upon obtaining his Ph.D. in early 1989, Athanasiou became an assistant professor at the University of Texas Health Science Center at San Antonio. He became an associate professor in 1994. He was recruited to Rice University as a full professor of bioengineering at the end of 1999. His group has worked extensively on cartilages of the musculoskeletal system both in terms of characterization but also in efforts to achieve healing or repair of the clinically complex problems of cartilage afflictions, including trauma and osteoarthritis.

Athanasiou published one of the first papers on the use of biodegradable scaffolds as carriers of growth factors to heal cartilage defects in vivo.[1] Four of his papers on identifying structure-function relationships in articular cartilage are standard in the field. His group has directed his attention to tissue engineering the jaw joint disc (TMJ disc) and the knee meniscus, whose degradation is responsible for a large number of debilitating problems. TMJ disc degeneration and meniscus injuries result in arthritic-like diseases that strike otherwise healthy young adults. In addition to tissue-level work, Athanasiou has established a highly innovative program to understand how single cartilage cells behave under direct and controlled biomechanical loads, not only in terms of deformation but also in terms of changes in gene expression.[2] This work represents the first measurement of gene levels at the single cell level under varying biomechanical conditions. His group has also demonstrated the fabrication of entire sections of articular cartilage by self-assembly of cells, without the use of any scaffolds.[3] [4] Their group also demonstrated that hydrostatic pressure in conjunction with growth factors can have synergistic effects on the functional properties of engineered cartilage.[5] The biomechanical, histological, transcriptional, and biochemical properties of this engineered cartilage approach those of native articular cartilage. An interesting paper on why cartilage healing is so difficult was also published in Science (journal) in 2012.[6] A relevant podcast is also available. [7]

High-technology companies[edit]

In addition to his academic accomplishments, Athanasiou is known for his significant contributions in co-founding five companies based on technologies co-developed by his group. His first company Osteobiologics, founded in 1993, was based, among other inventions, on the development of acellular scaffolds for the treatment of focal cartilage lesions. This was the first ever implant for this application. The company was acquired by Smith & Nephew in 2006. Another company co-founded by Athanasiou is Vidacare based on Athanasiou et al.'s patents on intraosseous infusion.

Service to the biomedical engineering profession[edit]

In the Summer of 2002, Professor Athanasiou was elected President of the Biomedical Engineering Society. He served as BMES President from 2003-04. During his tenure, BMES assumed accreditation responsibilities becoming a member of the Accreditation Board for Engineering and Technology (ABET). Also, the Annals of Biomedical Engineering, the flagship publication of BMES, changed publishers and format. Regional industry sections of BMES were also established and the first international affiliates program was initiated.

Honors[edit]

In November 2012, he received the Nemitsas Prize, which is considered to be the Nobel prize equivalent for people of Cypriot descent (NemitsasFoundation.org). Please also see his speech in Greek here: (Athanasiou speech at Nemitsas Foundation ceremony)

References[edit]

  1. ^ Athanasiou, K.A.; Korvick, D.; Schenck, R.C.: Biodegradable implants for the treatment of osteochondral defects in a goat model. Tissue Engineering, Vol. 3(4): 363-374, 1997.
  2. ^ Leipzig, N.; Athanasiou, K.A.: Static compression of single chondrocytes catabolically modifies single cell gene expression. Biophysical Journal, 94(6):2412-2422, 2008
  3. ^ Hu, J.C.; Athanasiou, K.A.: A self-assembling process in articular cartilage tissue engineering. Tissue Engineering, 12(4):969-979, 2006
  4. ^ Ofek, G.; Revell, C.M.; Hu, J.C.; Allison, D.D.; Grande-Allen, K.J.; Athanasiou, K.A.: Matrix development in self-assembly of articular cartilage. PLoS ONE, 3(7): e2795. doi:10.1371/journal.pone.0002795, 2008
  5. ^ Elder, B.D.; Athanasiou, K.A.: Synergistic and additive effects of hydrostatic pressure and growth factors on tissue formation. PLoS ONE, 3(6): e2341. doi:10.1371/journal.pone.0002341, 2008
  6. ^ Huey, D.; Hu, J.C.; Athanasiou, K.A.: Unlike bone, cartilage regeneration remains elusive, Science, 338:917-921, DOI: 10.1126/science.1222454, 2012
  7. ^ Full show- http://www.sciencemag.org/content/338/6109/981.2.full. Athanasiou's segment is at http://www.sciencemag.org/content/338/6109/917/suppl/DC2