L'isola di niente is a progressive rock album which has been described as being more complex than their previous records, additionally incorporating elements of jazz rock. In an Allmusic review, the album was given a positive review, being deemed PFM's last masterpiece, yet was rated slightly lower than their previous records. Tracks such as "La Luna Nuova" and "Dolcissima Maria" continue to be performed in their live set.
L'isola di niente is a progressive rock album at its core, yet shows greater influences from jazz fusion music. Described as more complex and confusing than their previous records, it ranges from symphonic rock-oriented progressive songs ("La Luna Nuova") to jazz rock-influenced pieces ("Via Lumiere"). The lyrics are also sung in Italian, with the exception of the second track, "Is My Face on Straight?". The album contains the presence of long tracks, especially "L'isola di niente" which is 10:48 minutes long, and makes usage of a backing choir as well as drums.
In an Allmusic review, François Couture wrote positively on the album, giving it a four out of five star rating, and labelling it a "masterpiece" and "one of the first Italian progressive rock wave's finest records", despite deeming it more "confusing" than its predecessors and "more of an acquired taste".