L-741,626 is a drug which acts as a potent and selective antagonist for the dopaminereceptorD2. It has good selectivity over the related D3 and D4 subtypes and other receptors. L-741,626 is used for laboratory research into brain function and has proved particularly useful for distinguishing D2 mediated responses from those produced by the closely related D3 subtype, and for studying the roles of these subtypes in the action of cocaine and amphetamines in the brain.
^Canales JJ, Iversen SD (September 2000). "Psychomotor-activating effects mediated by dopamine D(2) and D(3) receptors in the nucleus accumbens". Pharmacology, Biochemistry, and Behavior67 (1): 161–8. doi:10.1016/S0091-3057(00)00311-7. PMID11113496.
^Costanza RM, Barber DJ, Terry P (November 2001). "Antagonism of the discriminative stimulus effects of cocaine at two training doses by dopamine D2-like receptor antagonists". Psychopharmacology158 (2): 146–53. doi:10.1007/s002130100872. PMID11702088.
^Chaperon F, Tricklebank MD, Unger L, Neijt HC (June 2003). "Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors". Neuropharmacology44 (8): 1047–53. doi:10.1016/S0028-3908(03)00113-8. PMID12763098.
^Depoortère R, Bardin L, Rodrigues M, Abrial E, Aliaga M, Newman-Tancredi A (July 2009). "Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors". Behavioural Pharmacology20 (4): 303–11. doi:10.1097/FBP.0b013e32832ec5aa. PMID19584712.
^Watson DJ, Marsden CA, Millan MJ, Fone KC (March 2011). "Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment". The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)15 (4): 1–14. doi:10.1017/S1461145711000435. PMID21414250.