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L-759,656 is an analgesic drug that is a cannabinoid agonist. It is a highly selective agonist for the CB2 receptor, with selectivity of 414x for CB2 over CB1, although it is still not as selective as newer agents such as HU-308.
It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB1 activity, and a relatively strong antiinflammatory effect due to its strong activity at CB2.
- Ross, R.; Brockie, H.; Stevenson, L.; Murphy, V.; Templeton, F.; Makriyannis, A.; Pertwee, R. (1999). "Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630". British Journal of Pharmacology 126 (3): 665–672. doi:10.1038/sj.bjp.0702351. PMC 1565857. PMID 10188977.
- Huffman, J. W. (2000). "The search for selective ligands for the CB2 receptor". Current pharmaceutical design 6 (13): 1323–1337. doi:10.2174/1381612003399347. PMID 10903395.
- Huffman, J. W. (2005). "CB2 receptor ligands". Mini reviews in medicinal chemistry 5 (7): 641–649. doi:10.2174/1389557054368844. PMID 16026310.
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