L-aminoadipate-semialdehyde dehydrogenase

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L-aminoadipate-semialdehyde dehydrogenase
Identifiers
EC number 1.2.1.31
CAS number 9067-87-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) is an enzyme that catalyzes the chemical reaction

L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O \rightleftharpoons L-2-aminoadipate + NAD(P)H + H+

The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD+, NADP+, and H2O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H+.

This enzyme participates in lysine biosynthesis and biodegradation.

Nomenclature[edit]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include:

  • aminoadipate semialdehyde dehydrogenase,
  • 2-aminoadipate semialdehyde dehydrogenase,
  • alpha-aminoadipate-semialdehyde dehydrogenase,
  • alpha-aminoadipate reductase,
  • 2-aminoadipic semialdehyde dehydrogenase,
  • L-alpha-aminoadipate delta-semialdehyde oxidoreductase,
  • L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase,
  • L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine,
  • and dinucleotide oxidoreductase.

References[edit]

  • Calvert AF, Rodwell VW (1966). "Metabolism of pipecolic acid in a Pseudomonas species. 3 L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase". J. Biol. Chem. 241 (2): 409–14. PMID 4285660.