L-selectin

Selectin L
Rendering based on PDB 1KJB.
Available structures PDB 1KJB, 3CFW
Identifiers
Symbols	SELL; CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL; LYAM1; PLNHR; TQ1
External IDs	OMIM: 153240 MGI: 98279 HomoloGene: 539 GeneCards: SELL Gene
Gene Ontology Molecular function • protease binding • protein binding • sugar binding • heparin binding • carbohydrate binding • glycosphingolipid binding Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • cell adhesion • blood coagulation • regulation of immune response • leukocyte migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6402	20343
Ensembl	ENSG00000188404	ENSMUSG00000026581
UniProt	P14151	Q3TA36
RefSeq (mRNA)	NM_000655.4	NM_011346
RefSeq (protein)	NP_000646.2	NP_035476
Location (UCSC)	Chr 1: 169.66 – 169.68 Mb	Chr 1: 165.99 – 166.01 Mb
PubMed search	[1]	[2]

L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by ADAM17.

SELL is a cell surface component that is a member of a family of adhesion/homing receptors that play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4-binding proteins.

Ligands

• GlyCAM-1, found in the high endothelial venules of the lymph nodes.
• CD34, found on endothelial cells.
• MadCAM-1, found on endothelial cells of gut-associated lymphoid tissue.
• PSGL-1, binds with low affinity.

Function

L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. The receptor is commonly found on the cell surfaces of T cells. Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs. Here they reside ready to proliferate upon re-encountering antigen. Effector/memory T-lymphocytes do not express L-selectin, as they circulate in the periphery and have immediate effector functions upon encountering antigen.

External links

• MeSH L-Selectin
• Immunology at MCG 1/physresp

Further reading

• Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms". Curr. Opin. Immunol. 4 (1): 33–7. doi:10.1016/0952-7915(92)90120-4. PMID 1375831. 
• Nicholson IC (2003). "CD62L (L-selectin)". J. Biol. Regul. Homeost. Agents 16 (2): 144–6. PMID 12144128. 
• Ivetic A, Ridley AJ (2005). "The telling tail of L-selectin". Biochem. Soc. Trans. 32 (Pt 6): 1118–21. doi:10.1042/BST0321118. PMID 15506984. 
• Lasky LA, Singer MS, Dowbenko D et al (1992). "An endothelial ligand for L-selectin is a novel mucin-like molecule". Cell 69 (6): 927–38. doi:10.1016/0092-8674(92)90612-G. PMID 1376638. 
• Ord DC, Ernst TJ, Zhou LJ et al (1990). "Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils". J. Biol. Chem. 265 (14): 7760–7. PMID 1692315. 
• Bevilacqua M, Butcher E, Furie B et al (1991). "Selectins: a family of adhesion receptors". Cell 67 (2): 233. doi:10.1016/0092-8674(91)90174-W. PMID 1717161. 
• Tedder TF, Isaacs CM, Ernst TJ et al (1989). "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins". J. Exp. Med. 170 (1): 123–33. doi:10.1084/jem.170.1.123. PMC 2189363. PMID 2473156. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2189363. 
• Camerini D, James SP, Stamenkovic I, Seed B (1989). "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor". Nature 342 (6245): 78–82. doi:10.1038/342078a0. PMID 2509939. 
• Bowen BR, Nguyen T, Lasky LA (1989). "Characterization of a human homologue of the murine peripheral lymph node homing receptor". J. Cell Biol. 109 (1): 421–7. doi:10.1083/jcb.109.1.421. PMC 2115458. PMID 2663882. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2115458. 
• Siegelman MH, Weissman IL (1989). "Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5562–6. doi:10.1073/pnas.86.14.5562. PMC 336895. PMID 2664786. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=336895. 
• Bajorath J, Aruffo A (1995). "A template for generation and comparison of three-dimensional selectin models". Biochem. Biophys. Res. Commun. 216 (3): 1018–23. doi:10.1006/bbrc.1995.2722. PMID 7488174. 
• Dianzani U, Bragardo M, Buonfiglio D et al (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Brenner B, Gulbins E, Schlottmann K et al (1997). "L-selectin activates the Ras pathway via the tyrosine kinase p56lck". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15376–81. doi:10.1073/pnas.93.26.15376. PMC 26412. PMID 8986819. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26412. 
• Zöllner O, Lenter MC, Blanks JE et al (1997). "L-selectin from human, but not from mouse neutrophils binds directly to E-selectin". J. Cell Biol. 136 (3): 707–16. doi:10.1083/jcb.136.3.707. PMC 2134294. PMID 9024699. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2134294. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Prakobphol A, Thomsson KA, Hansson GC et al (1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity". Biochemistry 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010. 
• Sassetti C, Tangemann K, Singer MS et al (1998). "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34". J. Exp. Med. 187 (12): 1965–75. doi:10.1084/jem.187.12.1965. PMC 2212365. PMID 9625756. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212365. 
• Malhotra R, Ward M, Sim RB, Bird MI (1999). "Identification of human complement Factor H as a ligand for L-selectin". Biochem. J. 341 (1): 61–9. doi:10.1042/0264-6021:3410061. PMC 1220330. PMID 10377245. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220330. 
• Bradley LM, Duncan DD,Tonkonogy S, Swain SL (1999). "CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma". J. Exp. Med. 174 (3): 547–59. doi:10.1084/jem.174.3.547. PMC 2118927. PMID 1678774. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2118927. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.