LAG3

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Lymphocyte-activation gene 3
Identifiers
Symbols LAG3 ; CD223
External IDs OMIM153337 MGI106588 HomoloGene1719 GeneCards: LAG3 Gene
RNA expression pattern
PBB GE LAG3 206486 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3902 16768
Ensembl ENSG00000089692 ENSMUSG00000030124
UniProt P18627 Q61790
RefSeq (mRNA) NM_002286 NM_008479
RefSeq (protein) NP_002277 NP_032505
Location (UCSC) Chr 12:
6.88 – 6.89 Mb
Chr 6:
124.9 – 124.91 Mb
PubMed search [1] [2]

Lymphocyte-activation gene 3, also known as LAG3, is a protein which in humans is encoded by the LAG3 gene.[1][2] LAG3 has also recently been designated CD223 (cluster of differentiation 223).

Lymphocyte-activation protein 3 belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.[1]

References[edit]

  1. ^ a b "Entrez Gene: LAG3 lymphocyte-activation gene 3". 
  2. ^ Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas-Pequignot E, Hercend T (May 1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393–405. doi:10.1084/jem.171.5.1393. PMC 2187904. PMID 1692078. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.