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Lymphocyte-activation gene 3
Symbols LAG3 ; CD223
External IDs OMIM153337 MGI106588 HomoloGene1719 GeneCards: LAG3 Gene
RNA expression pattern
PBB GE LAG3 206486 at tn.png
More reference expression data
Species Human Mouse
Entrez 3902 16768
Ensembl ENSG00000089692 ENSMUSG00000030124
UniProt P18627 Q61790
RefSeq (mRNA) NM_002286 NM_008479
RefSeq (protein) NP_002277 NP_032505
Location (UCSC) Chr 12:
6.88 – 6.89 Mb
Chr 6:
124.9 – 124.91 Mb
PubMed search [1] [2]

Lymphocyte-activation gene 3, also known as LAG3, is a protein which in humans is encoded by the LAG3 gene.[1][2] LAG3 has also recently been designated CD223 (cluster of differentiation 223).

Lymphocyte-activation protein 3 belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.[1]


  1. ^ a b "Entrez Gene: LAG3 lymphocyte-activation gene 3". 
  2. ^ Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas-Pequignot E, Hercend T (May 1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393–405. doi:10.1084/jem.171.5.1393. PMC 2187904. PMID 1692078. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.