LAIR1
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| Leukocyte-associated immunoglobulin-like receptor 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LAIR1; CD305; LAIR-1 | ||||||||||||
| External IDs | OMIM: 602992 MGI: 105492 HomoloGene: 48097 GeneCards: LAIR1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3903 | 52855 | |||||||||||
| Ensembl | ENSG00000167613 | ENSMUSG00000055541 | |||||||||||
| UniProt | Q6GTX8 | Q8BG84 | |||||||||||
| RefSeq (mRNA) | NM_002287.3 | NM_178611 | |||||||||||
| RefSeq (protein) | NP_002278.1 | NP_848726 | |||||||||||
| Location (UCSC) | Chr 19: 54.87 – 54.88 Mb |
Chr 7: 3.96 – 4.01 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[1][2] LAIR1 has also been designated as CD305 (cluster of differentiation 305).
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[2]
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[edit] Interactions
LAIR1 has been shown to interact with PTPN11[3][1] and PTPN6.[4][3][1][5][6]
[edit] References
- ^ a b c Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (Sep 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412.
- ^ a b "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3903.
- ^ a b Fournier, N; Chalus L, Durand I, Garcia E, Pin J J, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates E E, Garrone P (Aug. 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. (UNITED STATES) 165 (3): 1197–209. ISSN 0022-1767. PMID 10903717.
- ^ Sathish, J G; Johnson K G, Fuller K J, LeRoy F G, Meyaard L, Sims M J, Matthews R J (Feb. 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. (United States) 166 (3): 1763–70. ISSN 0022-1767. PMID 11160222.
- ^ Mousseau, D D; Banville D, L'Abbé D, Bouchard P, Shen S H (Feb. 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J. Biol. Chem. (UNITED STATES) 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. ISSN 0021-9258. PMID 10660620.
- ^ Xu, M j; Zhao R, Zhao Z J (Jun. 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. (UNITED STATES) 275 (23): 17440–6. doi:10.1074/jbc.M001313200. ISSN 0021-9258. PMID 10764762.
[edit] Further reading
- Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. doi:10.1046/j.1365-3083.1999.00580.x. PMID 10404045.
- Meyaard L (1999). "LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells". Curr. Top. Microbiol. Immunol.. Current Topics in Microbiology 244 and Immunology 244: 151–7. doi:10.1007/978-3-642-58537-1_13. ISBN 978-3-540-65789-7. PMID 10453657.
- Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents 17 (4): 330–3. PMID 15065762.
- Poggi A, Tomasello E, Ferrero E et al (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. PMID 9692876.
- Meyaard L, Hurenkamp J, Clevers H et al (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. PMID 10229813.
- van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". Eur. J. Immunol. 29 (10): 3160–7. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327.
- Xu M, Zhao R, Zhao ZJ (2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. doi:10.1074/jbc.M001313200. PMID 10764762.
- Poggi A, Pellegatta F, Leone BE et al (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. PMID 11069054.
- Sathish JG, Johnson KG, Fuller KJ et al (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. PMID 11160222.
- Meyaard L, van der Vuurst de Vries AR, de Ruiter T et al (2001). "The Epithelial Cellular Adhesion Molecule (EP-Cam) Is a Ligand for the Leukocyte-Associated Immunoglobulin-like Receptor (Lair)". J. Exp. Med. 194 (1): 107–12. doi:10.1084/jem.194.1.107. PMC 2193444. PMID 11435477. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193444.
- Saverino D, Fabbi M, Merlo A et al (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. doi:10.1016/S0198-8859(02)00409-3. PMID 12072189.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Aoukaty A, Lee IF, Wu J, Tan R (2004). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. doi:10.1023/A:1022580929226. PMID 12757266.
- Verbrugge A, Ruiter Td T, Clevers H, Meyaard L (2004). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. doi:10.1093/intimm/dxg134. PMID 14565933.
- De Milito A, Nilsson A, Titanji K et al (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood 103 (6): 2180–6. doi:10.1182/blood-2003-07-2375. PMID 14604962.
- Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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