From Wikipedia, the free encyclopedia
Jump to: navigation, search
Leukocyte-associated immunoglobulin-like receptor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LAIR1 ; CD305; LAIR-1
External IDs OMIM602992 MGI105492 HomoloGene48097 GeneCards: LAIR1 Gene
RNA expression pattern
PBB GE LAIR1 210644 s at tn.png
PBB GE LAIR1 208071 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3903 52855
Ensembl ENSG00000167613 ENSMUSG00000055541
UniProt Q6GTX8 Q8BG84
RefSeq (mRNA) NM_002287 NM_001113474
RefSeq (protein) NP_002278 NP_001106945
Location (UCSC) Chr 19:
54.87 – 54.88 Mb
Chr 7:
4.01 – 4.06 Mb
PubMed search [1] [2]

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[1][2] LAIR1 has also been designated as CD305 (cluster of differentiation 305).

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[2]


LAIR1 has been shown to interact with PTPN11[1][3] and PTPN6.[1][3][4][5][6]


  1. ^ a b c Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (September 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412. 
  2. ^ a b "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1". 
  3. ^ a b Fournier, N; Chalus L, Durand I, Garcia E, Pin J J, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates E E, Garrone P (August 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. (UNITED STATES) 165 (3): 1197–209. ISSN 0022-1767. PMID 10903717. 
  4. ^ Sathish, J G; Johnson K G; Fuller K J; LeRoy F G; Meyaard L; Sims M J; Matthews R J (February 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. (United States) 166 (3): 1763–70. ISSN 0022-1767. PMID 11160222. 
  5. ^ Mousseau, D D; Banville D, L'Abbé D, Bouchard P, Shen S H (February 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J. Biol. Chem. (UNITED STATES) 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. ISSN 0021-9258. PMID 10660620. 
  6. ^ Xu, M j; Zhao R; Zhao Z J (June 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. (UNITED STATES) 275 (23): 17440–6. doi:10.1074/jbc.M001313200. ISSN 0021-9258. PMID 10764762. 

Further reading[edit]

  • Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. doi:10.1046/j.1365-3083.1999.00580.x. PMID 10404045. 
  • Meyaard L (1999). "LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells". Curr. Top. Microbiol. Immunol. Current Topics in Microbiology 244 and Immunology 244: 151–7. doi:10.1007/978-3-642-58537-1_13. ISBN 978-3-540-65789-7. PMID 10453657. 
  • Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents 17 (4): 330–3. PMID 15065762. 
  • Poggi A, Tomasello E, Ferrero E et al. (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. PMID 9692876. 
  • Meyaard L, Hurenkamp J, Clevers H et al. (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. PMID 10229813. 
  • van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". Eur. J. Immunol. 29 (10): 3160–7. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327. 
  • Xu M, Zhao R, Zhao ZJ (2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. doi:10.1074/jbc.M001313200. PMID 10764762. 
  • Poggi A, Pellegatta F, Leone BE et al. (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. PMID 11069054. 
  • Sathish JG, Johnson KG, Fuller KJ et al. (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. PMID 11160222. 
  • Saverino D, Fabbi M, Merlo A et al. (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. doi:10.1016/S0198-8859(02)00409-3. PMID 12072189. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Aoukaty A, Lee IF, Wu J, Tan R (2004). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. doi:10.1023/A:1022580929226. PMID 12757266. 
  • Verbrugge A, Ruiter Td T, Clevers H, Meyaard L (2004). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. doi:10.1093/intimm/dxg134. PMID 14565933. 
  • De Milito A, Nilsson A, Titanji K et al. (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood 103 (6): 2180–6. doi:10.1182/blood-2003-07-2375. PMID 14604962. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.