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Leukocyte-associated immunoglobulin-like receptor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LAIR1 ; CD305; LAIR-1
External IDs OMIM602992 MGI105492 HomoloGene48097 GeneCards: LAIR1 Gene
RNA expression pattern
PBB GE LAIR1 210644 s at tn.png
PBB GE LAIR1 208071 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3903 52855
Ensembl ENSG00000167613 ENSMUSG00000055541
UniProt Q6GTX8 Q8BG84
RefSeq (mRNA) NM_001289023 NM_001113474
RefSeq (protein) NP_001275952 NP_001106945
Location (UCSC) Chr 19:
54.87 – 54.88 Mb
Chr 7:
4.01 – 4.06 Mb
PubMed search [1] [2]

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[1][2] LAIR1 has also been designated as CD305 (cluster of differentiation 305).

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[2]


LAIR1 has been shown to interact with PTPN11[1][3] and PTPN6.[1][3][4][5][6]


  1. ^ a b c Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (September 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412. 
  2. ^ a b "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1". 
  3. ^ a b Fournier, N; Chalus L, Durand I, Garcia E, Pin J J, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates E E, Garrone P (August 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. (UNITED STATES) 165 (3): 1197–209. doi:10.4049/jimmunol.165.3.1197. ISSN 0022-1767. PMID 10903717. 
  4. ^ Sathish, J G; Johnson K G; Fuller K J; LeRoy F G; Meyaard L; Sims M J; Matthews R J (February 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. (United States) 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. ISSN 0022-1767. PMID 11160222. 
  5. ^ Mousseau, D D; Banville D; L'Abbé D; Bouchard P; Shen S H (February 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J. Biol. Chem. (UNITED STATES) 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. ISSN 0021-9258. PMID 10660620. 
  6. ^ Xu, M j; Zhao R; Zhao Z J (June 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. (UNITED STATES) 275 (23): 17440–6. doi:10.1074/jbc.M001313200. ISSN 0021-9258. PMID 10764762. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.