LAPTM4B

Lysosomal protein transmembrane 4 beta
Identifiers
Symbols	LAPTM4B; LAPTM4beta; LC27
External IDs	OMIM: 613296 MGI: 1890494 HomoloGene: 10182 GeneCards: LAPTM4B Gene
Gene Ontology Molecular function • protein binding Cellular component • endomembrane system • membrane • integral to membrane Biological process • transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55353	114128
Ensembl	ENSG00000104341	ENSMUSG00000022257
UniProt	Q86VI4	Q91XQ6
RefSeq (mRNA)	NM_018407	NM_033521.3
RefSeq (protein)	NP_060877	NP_277056.1
Location (UCSC)	Chr 8: 98.79 – 98.87 Mb	Chr 15: 34.17 – 34.21 Mb
PubMed search	[1]	[2]

Lysosomal-associated transmembrane protein 4B is a protein that in humans is encoded by the LAPTM4B gene.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• With S, Rice T, Salinas C, Auld V (2003). "Fire exit is a potential four transmembrane protein expressed in developing Drosophila glia.". Genesis 35 (3): 143–52. doi:10.1002/gene.10177. PMID 12640618. 
• Shao GZ, Zhou RL, Zhang QY, et al. (2003). "Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma.". Oncogene 22 (32): 5060–9. doi:10.1038/sj.onc.1206832. PMID 12902989. 
• Liu XR, Zhou RL, Zhang QY, et al. (2004). "Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma.". World J. Gastroenterol. 10 (11): 1555–9. PMID 15162524. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Kasper G, Vogel A, Klaman I, et al. (2005). "The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression.". Cancer Lett. 224 (1): 93–103. doi:10.1016/j.canlet.2004.10.004. PMID 15911104. 
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501. 
• Maeda K, Horikoshi T, Nakashima E, et al. (2007). "MATN and LAPTM are parts of larger transcription units produced by intergenic splicing: intergenic splicing may be a common phenomenon.". DNA Res. 12 (5): 365–72. doi:10.1093/dnares/dsi017. PMID 16769693. 
• Liu Y, Zhang QY, Qian N, Zhou RL (2007). "Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer.". Ann. Oncol. 18 (2): 311–6. doi:10.1093/annonc/mdl394. PMID 17074969.