LARP1
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| La ribonucleoprotein domain family, member 1 | |||||||||
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| Identifiers | |||||||||
| Symbols | LARP1; KIAA0731; LARP; MGC19556 | ||||||||
| External IDs | OMIM: 612059 MGI: 1890165 HomoloGene: 9089 GeneCards: LARP1 Gene | ||||||||
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| RNA expression pattern | |||||||||
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| More reference expression data | |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 23367 | 73158 | |||||||
| Ensembl | ENSG00000155506 | ENSMUSG00000037331 | |||||||
| UniProt | Q6PKG0 | n/a | |||||||
| RefSeq (mRNA) | NM_015315 | NM_028451.1 | |||||||
| RefSeq (protein) | NP_056130 | NP_082727.1 | |||||||
| Location (UCSC) | Chr 5: 154.09 – 154.2 Mb |
Chr 11: 57.82 – 57.88 Mb |
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| PubMed search | [1] | [2] | |||||||
La-related protein 1 is a protein that in humans is encoded by the LARP1 gene.[1][2][3][1][2]
[edit] Function
All LARP proteins, including human LARP, contain 2 conserved regions. The first conserved region shares homology with La proteins (called the La motif, see SSB) whereas the second conserved region (called the LARP1 motif) is restricted to LARP proteins. Mouse Larp1 is expressed in dorsal root ganglia and spinal cord, as well as in developing organs characterized by epithelial-mesenchymal interactions.[2]
LARP-1 appears to bind mRNA in vitro via both the La motif and the LARP1 domain. LARP-1 also appears to down-regulate the Ras-MAPK pathway. LARP-1 protein colocalizes with P bodies, which function in RNA degradation. We suggest that LARP-1 functions in P-bodies to attenuate the abundance of conserved Ras-MAPK mRNAs. The cluster of LARP-1 homologs may function to control the expression of key developmental regulators.[4]
[edit] References
- ^ a b Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- ^ a b c Chauvet S, Maurel-Zaffran C, Miassod R, Jullien N, Pradel J, Aragnol D (Aug 2000). "dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions". Dev Dyn 218 (3): 401–13. doi:10.1002/1097-0177(200007)218:3<401::AID-DVDY1009>3.0.CO;2-6. PMID 10878606.
- ^ "Entrez Gene: LARP1 La ribonucleoprotein domain family, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23367.
- ^ Nykamp K, Lee MH, Kimble J (July 2008). "C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis". RNA 14 (7): 1378–89. doi:10.1261/rna.1066008. PMC 2441978. PMID 18515547. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2441978.
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Horke S, Reumann K, Schweizer M et al (2004). "Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA". J. Biol. Chem. 279 (25): 26563–70. doi:10.1074/jbc.M401017200. PMID 15060081.
- Beausoleil SA, Jedrychowski M, Schwartz D et al (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Jin J, Smith FD, Stark C et al (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Beausoleil SA, Villén J, Gerber SA et al (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Olsen JV, Blagoev B, Gnad F et al (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F et al (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
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