LARP6

LARP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MTF, 2MTG
Identifiers
Aliases	LARP6, ACHN, La ribonucleoprotein domain family member 6, La ribonucleoprotein 6, translational regulator
External IDs	OMIM: 611300 MGI: 1914807 HomoloGene: 32408 GeneCards: LARP6
Gene location (Human) Chr. Chromosome 15 (human) Band 15q23 Start 70,829,130 bp End 70,854,157 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 60,620,272 bp End 60,646,084 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus inferior ganglion of vagus nerve gastric mucosa subthalamic nucleus inferior olivary nucleus pons putamen ventral tegmental area sperm superior vestibular nucleus Top expressed in pontine nuclei lateral geniculate nucleus superior colliculus anterior horn of spinal cord dorsal tegmental nucleus lateral hypothalamus ventral tegmental area piriform cortex facial motor nucleus nucleus accumbens More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding nucleic acid binding protein binding sequence-specific mRNA binding myosin binding RNA stem-loop binding mRNA 5'-UTR binding Cellular component cytoplasm nucleus polysome ribonucleoprotein complex Biological process RNA processing regulation of translation positive regulation of collagen biosynthetic process positive regulation of translation positive regulation of mRNA binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55323 67557 Ensembl ENSG00000166173 ENSMUSG00000034839 UniProt Q9BRS8 Q8BN59 RefSeq (mRNA) NM_197958 NM_001286679 NM_018357 NM_026235 RefSeq (protein) NP_001273608 NP_060827 NP_932062 NP_080511 Location (UCSC) Chr 15: 70.83 – 70.85 Mb Chr 9: 60.62 – 60.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

La-related protein 6 also known as acheron or La ribonucleoprotein domain family member 6 (LARP6), is a protein that in humans is encoded by the LARP6 gene.

Clinical relevance

In a recent genome-wide association study, LARP6 gene has been associated with fasting glucose traits, type 2 diabetes and obesity.

Further reading

• Cai L, Fritz D, Stefanovic L, Stefanovic B (2010). "Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen". J. Mol. Biol. 395 (2): 309–26. doi:10.1016/j.jmb.2009.11.020. PMC 2826804. PMID 19917293.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Glenn HL, Wang Z, Schwartz LM (2010). "Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts". Am. J. Physiol., Cell Physiol. 298 (1): C46–55. doi:10.1152/ajpcell.00387.2009. PMC 2806151. PMID 19889961.
• Valavanis C, Wang Z, Sun D, et al. (2007). "Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta". Gene. 393 (1–2): 101–9. doi:10.1016/j.gene.2007.01.033. PMC 2739619. PMID 17383118.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.