LATS1

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Large tumor suppressor kinase 1
Identifiers
Symbols LATS1 ; WARTS; wts
External IDs OMIM603473 MGI1333883 HomoloGene55843 ChEMBL: 6167 GeneCards: LATS1 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE LATS1 219813 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9113 16798
Ensembl ENSG00000131023 ENSMUSG00000040021
UniProt O95835 Q8BYR2
RefSeq (mRNA) NM_001270519 NM_010690
RefSeq (protein) NP_001257448 NP_034820
Location (UCSC) Chr 6:
149.98 – 150.04 Mb
Chr 10:
7.68 – 7.72 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.[1][2][3]

It has been associated with the Hippo signaling pathway.[4]

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.[3]

Interactions[edit]

LATS1 has been shown to interact with Zyxin[5] and Cdk1.[1]

References[edit]

  1. ^ a b Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T (February 1999). "Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity". Nat Genet 21 (2): 177–81. doi:10.1038/5960. PMID 9988268. 
  2. ^ Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H (July 2004). "Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function". Oncogene 23 (31): 5266–74. doi:10.1038/sj.onc.1207623. PMID 15122335. 
  3. ^ a b "Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)". 
  4. ^ Hao Y, Chun A, Cheung K, Rashidi B, Yang X (February 2008). "Tumor suppressor LATS1 is a negative regulator of oncogene YAP". J. Biol. Chem. 283 (9): 5496–509. doi:10.1074/jbc.M709037200. PMID 18158288. 
  5. ^ Hirota, T; Morisaki T; Nishiyama Y; Marumoto T; Tada K; Hara T; Masuko N; Inagaki M; Hatakeyama K; Saya H (May 2000). "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor". J. Cell Biol. (UNITED STATES) 149 (5): 1073–86. doi:10.1083/jcb.149.5.1073. ISSN 0021-9525. PMC 2174824. PMID 10831611. 

Further reading[edit]