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LCMS may refer to:
Science and technology
- Liquid chromatography–mass spectrometry, a chemical analysis technique
- Learning content management system
- LittleCMS, an open-source color management system
- Lindero Canyon Middle School, Agoura Hills, CA, USA
- Los Cerritos Middle School, Thousand Oaks, CA, USA
- Lutheran Church–Missouri Synod, a conservative Lutheran body in the United States
- Lutheran Church in Malaysia and Singapore
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