LCP1

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Lymphocyte cytosolic protein 1 (L-plastin)
Protein LCP1 PDB 2d85.png
PDB rendering based on 2d85.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LCP1 ; CP64; HEL-S-37; L-PLASTIN; LC64P; LPL; PLS2
External IDs OMIM153430 MGI104808 HomoloGene80174 GeneCards: LCP1 Gene
RNA expression pattern
PBB GE LCP1 208885 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3936 18826
Ensembl ENSG00000136167 ENSMUSG00000021998
UniProt P13796 Q61233
RefSeq (mRNA) NM_002298 NM_001247984
RefSeq (protein) NP_002289 NP_001234913
Location (UCSC) Chr 13:
46.7 – 46.79 Mb
Chr 14:
75.13 – 75.23 Mb
PubMed search [1] [2]

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.[1]

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.[2]

References[edit]

  1. ^ Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y (Jun 1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry 29 (4): 1055–62. doi:10.1021/bi00456a030. PMID 2111166. 
  2. ^ "Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)". 

Further reading[edit]