LDOC1
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| Leucine zipper, down-regulated in cancer 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LDOC1; BCUR1; Mar7; Mart7 | ||||||||||||
| External IDs | OMIM: 300402 MGI: 2685212 HomoloGene: 32153 GeneCards: LDOC1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23641 | 434784 | |||||||||||
| Ensembl | ENSG00000182195 | ENSMUSG00000057615 | |||||||||||
| UniProt | O95751 | Q7TPY9 | |||||||||||
| RefSeq (mRNA) | NM_012317 | NM_001018087.1 | |||||||||||
| RefSeq (protein) | NP_036449 | NP_001018097.1 | |||||||||||
| Location (UCSC) | Chr X: 140.27 – 140.27 Mb |
Chr X: 58.96 – 58.96 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.[1][2][3][4]
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.[4]
[edit] Interactions
LDOC1 has been shown to interact with ABLIM1.[5]
[edit] References
- ^ Nagasaki K, Manabe T, Hanzawa H, Maass N, Tsukada T, Yamaguchi K (Aug 1999). "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines". Cancer Lett 140 (1–2): 227–34. doi:10.1016/S0304-3835(99)00087-7. PMID 10403563.
- ^ Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Apr 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.
- ^ Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenet Genome Res 110 (1–4): 307–17. doi:10.1159/000084963. PMID 16093683.
- ^ a b "Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23641.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Nagasaki K, Schem C, von Kaisenberg C, et al. (2003). "Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis". Int. J. Cancer 105 (4): 454–8. doi:10.1002/ijc.11122. PMID 12712434.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Chih DY, Park DJ, Gross M, et al. (2005). "Protein partners of C/EBPepsilon". Exp. Hematol. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
- Inoue M, Takahashi K, Niide O, et al. (2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Lett. 579 (3): 604–8. doi:10.1016/j.febslet.2004.12.030. PMID 15670815.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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