Leptin receptor

	Leptin receptor
	Identifiers
Symbols	LEPR; CD295; OBR
External IDs	OMIM: 601007 MGI: 104993 HomoloGene: 1731
Gene ontology
Molecular function:	• hematopoietin/interferon-class (D200-domain) cytokine receptor activity; • protein binding;
Cellular component:	• integral to plasma membrane; • membrane;
Biological process:	• energy reserve metabolic process; • cell surface receptor linked signal transduction; • multicellular organismal development;
	Orthologs

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Leptin receptor, also known as LEPR, is a human gene. LEPR has also been designated as CD295 (cluster of differentiation 295).

Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM]^[1]

It has been associated with obesity.^[2] In an animal model, induced swimming helped to overcome this condition by upregulating uncoupling proteins.^[3]

[edit] References

^ "Entrez Gene: LEPR leptin receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3953.
^ Masuo K, Straznicky NE, Lambert GW, et al. (June 2008). "Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population". Hypertens. Res. 31 (6): 1093–100. doi:10.1291/hypres.31.1093. PMID 18716356. http://dx.doi.org/10.1291/hypres.31.1093.
^ Oh KS, Kim EY, Yoon M, Lee CM (June 2007). "Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins". Exp. Mol. Med. 39 (3): 385–94. PMID 17603293. http://www.e-emm.org/search_read.htm?page=385&year=2007&vol=39.

[edit] Further reading

Heshka JT, Jones PJ (2001). "A role for dietary fat in leptin receptor, OB-Rb, function.". Life Sci. 69 (9): 987–1003. doi:10.1016/S0024-3205(01)01201-2. PMID 11508653.
Tartaglia LA, Dembski M, Weng X, et al. (1996). "Identification and expression cloning of a leptin receptor, OB-R.". Cell 83 (7): 1263–71. doi:10.1016/0092-8674(95)90151-5. PMID 8548812.
Chen H, Charlat O, Tartaglia LA, et al. (1996). "Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.". Cell 84 (3): 491–5. doi:10.1016/S0092-8674(00)81294-5. PMID 8608603.
Cioffi JA, Shafer AW, Zupancic TJ, et al. (1996). "Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.". Nat. Med. 2 (5): 585–9. doi:10.1038/nm0596-585. PMID 8616721.
Considine RV, Considine EL, Williams CJ, et al. (1996). "The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations.". Diabetes 45 (7): 992–4. doi:10.2337/diabetes.45.7.992. PMID 8666155.
Chung WK, Power-Kehoe L, Chua M, Leibel RL (1996). "Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human.". Genome Res. 6 (5): 431–8. doi:10.1101/gr.6.5.431. PMID 8743992.
Bennett BD, Solar GP, Yuan JQ, et al. (1997). "A role for leptin and its cognate receptor in hematopoiesis.". Curr. Biol. 6 (9): 1170–80. doi:10.1016/S0960-9822(02)70684-2. PMID 8805376.
Winick JD, Stoffel M, Friedman JM (1997). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1.". Genomics 36 (1): 221–2. doi:10.1006/geno.1996.0455. PMID 8812446.
Luoh SM, Di Marco F, Levin N, et al. (1997). "Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.". J. Mol. Endocrinol. 18 (1): 77–85. doi:10.1677/jme.0.0180077. PMID 9061609.
Echwald SM, Sørensen TD, Sørensen TI, et al. (1997). "Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.". Biochem. Biophys. Res. Commun. 233 (1): 248–52. doi:10.1006/bbrc.1997.6430. PMID 9144432.
Thompson DB, Ravussin E, Bennett PH, Bogardus C (1997). "Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians.". Hum. Mol. Genet. 6 (5): 675–9. doi:10.1093/hmg/6.5.675. PMID 9158141.
Gotoda T, Manning BS, Goldstone AP, et al. (1997). "Leptin receptor gene variation and obesity: lack of association in a white British male population.". Hum. Mol. Genet. 6 (6): 869–76. doi:10.1093/hmg/6.6.869. PMID 9175732.
Bailleul B, Akerblom I, Strosberg AD (1997). "The leptin receptor promoter controls expression of a second distinct protein.". Nucleic Acids Res. 25 (14): 2752–8. doi:10.1093/nar/25.14.2752. PMID 9207021.
Chung WK, Power-Kehoe L, Chua M, et al. (1997). "Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).". Diabetes 46 (9): 1509–11. PMID 9287054.
Bjørbaek C, Uotani S, da Silva B, Flier JS (1998). "Divergent signaling capacities of the long and short isoforms of the leptin receptor.". J. Biol. Chem. 272 (51): 32686–95. doi:10.1074/jbc.272.51.32686. PMID 9405487.
Clément K, Vaisse C, Lahlou N, et al. (1998). "A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.". Nature 392 (6674): 398–401. doi:10.1038/32911. PMID 9537324.
Carpenter LR, Farruggella TJ, Symes A, et al. (1998). "Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6061–6. doi:10.1073/pnas.95.11.6061. PMID 9600917.
Kielar D, Clark JS, Ciechanowicz A, et al. (1998). "Leptin receptor isoforms expressed in human adipose tissue.". Metab. Clin. Exp. 47 (7): 844–7. PMID 9667233.
Haniu M, Arakawa T, Bures EJ, et al. (1998). "Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.". J. Biol. Chem. 273 (44): 28691–9. doi:10.1074/jbc.273.44.28691. PMID 9786864.
Haft CR, de la Luz Sierra M, Barr VA, et al. (1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors.". Mol. Cell. Biol. 18 (12): 7278–87. PMID 9819414.

[edit] External links

MeSH LEPR+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[0] "Entrez Gene: LEPR leptin receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3953.

[pmid18716356-1] Masuo K, Straznicky NE, Lambert GW, et al. (June 2008). "Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population". Hypertens. Res. 31 (6): 1093–100. doi:10.1291/hypres.31.1093. PMID 18716356. http://dx.doi.org/10.1291/hypres.31.1093.

[pmid17603293-2] Oh KS, Kim EY, Yoon M, Lee CM (June 2007). "Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins". Exp. Mol. Med. 39 (3): 385–94. PMID 17603293. http://www.e-emm.org/search_read.htm?page=385&year=2007&vol=39.

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Leptin receptor

From Wikipedia, the free encyclopedia

[edit] References

[edit] Further reading

[edit] External links

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