LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, also known as LFNG and Lunatic Fringe, is a human gene.
This gene encodes a member of the glycosyltransferase superfamily. The encoded protein is a single-pass type II Golgi membrane protein that functions as a fucose-specific glycosyltransferase, adding an N-acetylglucosamine to the fucose residue of a group of signaling receptors involved in regulating cell fate decisions during development. Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3 Jarcho-Levin syndrome#Spondylocostal dysostosis. Alternatively spliced transcript variants that encode different isoforms have been described, however, not all variants have been fully characterized.
Johnston SH, Rauskolb C, Wilson R et al. (1997). "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway". Development124 (11): 2245–54. PMID9187150.
Moran JL, Johnston SH, Rauskolb C et al. (1999). "Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes". Mamm. Genome10 (6): 535–41. doi:10.1007/s003359901039. PMID10341080.
Moloney DJ, Panin VM, Johnston SH et al. (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature406 (6794): 369–75. doi:10.1038/35019000. PMID10935626.
Shimizu K, Chiba S, Saito T et al. (2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem.276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID11346656.
Shao L, Moloney DJ, Haltiwanger R (2003). "Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region". J. Biol. Chem.278 (10): 7775–82. doi:10.1074/jbc.M212221200. PMID12486116.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.