LGALS1

Lectin, galactoside-binding, soluble, 1
	; PDB rendering based on 1gzw.
Available structures
PDB	1GZW, 1W6M, 1W6N, 1W6O, 1W6P, 1W6Q, 2KM2, 2ZKN, 3OY8, 3OYW
Identifiers
Symbols	LGALS1; DKFZp686E23103; GAL1; GBP
External IDs	OMIM: 150570 MGI: 96777 HomoloGene: 7399 GeneCards: LGALS1 Gene
Gene Ontology
Molecular function	• glycoprotein binding; • signal transducer activity; • protein binding; • sugar binding; • galactoside binding; • lactose binding; • protein homodimerization activity; • laminin binding;
Cellular component	• extracellular region; • proteinaceous extracellular matrix; • extracellular space; • intracellular; • nucleus; • cytoplasm; • cell surface; • extracellular matrix;
Biological process	• apoptosis; • signal transduction; • negative regulation of cell-substrate adhesion; • negative regulation of neuron projection development; • multicellular organismal response to stress; • positive regulation of erythrocyte aggregation; • response to drug; • regulation of apoptosis; • positive regulation of I-kappaB kinase/NF-kappaB cascade; • myoblast differentiation; • response to axon injury; • cellular response to glucose stimulus; • cellular response to organic cyclic compound;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Galectin-1 is a protein that in humans is encoded by the LGALS1 gene.^[1]^[2]

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS1 may act as an autocrine negative growth factor that regulates cell proliferation.^[3]

[edit] Interactions

LGALS1 has been shown to interact with GEMIN4^[4] and HRAS.^[5]

[edit] See also

Galectin

[edit] References

^ Gitt MA, Barondes SH (February 1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry 30 (1): 82–9. doi:10.1021/bi00215a013. PMID 1988031.
^ Gauthier L, Rossi B, Roux F, Termine E, Schiff C (October 2002). "Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering". Proc Natl Acad Sci U S A 99 (20): 13014–9. doi:10.1073/pnas.202323999. PMC 130578. PMID 12271131. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=130578.
^ "Entrez Gene: LGALS1 lectin, galactoside-binding, soluble, 1 (galectin 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3956.
^ Park, J W; Voss P G, Grabski S, Wang J L, Patterson R J (September 2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. (England) 29 (17): 3595–602. doi:10.1093/nar/29.17.3595. PMC 55878. PMID 11522829. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55878.
^ Paz, A; Haklai R, Elad-Sfadia G, Ballan E, Kloog Y (November 2001). "Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation". Oncogene (England) 20 (51): 7486–93. doi:10.1038/sj.onc.1204950. ISSN 0950-9232. PMID 11709720.

[edit] Further reading

Barondes SH, Cooper DN, Gitt MA, Leffler H (1994). "Galectins. Structure and function of a large family of animal lectins". J. Biol. Chem. 269 (33): 20807–10. PMID 8063692.

This article on a gene on chromosome 22 is a stub. You can help Wikipedia by expanding it.

[pmid1988031-0] Gitt MA, Barondes SH (February 1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry 30 (1): 82–9. doi:10.1021/bi00215a013. PMID 1988031.

[pmid12271131-1] Gauthier L, Rossi B, Roux F, Termine E, Schiff C (October 2002). "Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering". Proc Natl Acad Sci U S A 99 (20): 13014–9. doi:10.1073/pnas.202323999. PMC 130578. PMID 12271131. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=130578.

[2] "Entrez Gene: LGALS1 lectin, galactoside-binding, soluble, 1 (galectin 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3956.

[pmid11522829-3] Park, J W; Voss P G, Grabski S, Wang J L, Patterson R J (September 2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. (England) 29 (17): 3595–602. doi:10.1093/nar/29.17.3595. PMC 55878. PMID 11522829. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55878.

[pmid11709720-4] Paz, A; Haklai R, Elad-Sfadia G, Ballan E, Kloog Y (November 2001). "Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation". Oncogene (England) 20 (51): 7486–93. doi:10.1038/sj.onc.1204950. ISSN 0950-9232. PMID 11709720.

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LGALS1

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[edit] Interactions

[edit] See also

[edit] References

[edit] Further reading

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