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Lectin, galactoside-binding, soluble, 2
Protein LGALS2 PDB 1hlc.png
PDB rendering based on 1hlc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LGALS2 ; HL14
External IDs OMIM150571 MGI895068 HomoloGene4741 ChEMBL: 5977 GeneCards: LGALS2 Gene
RNA expression pattern
PBB GE LGALS2 208450 at tn.png
More reference expression data
Species Human Mouse
Entrez 3957 107753
Ensembl ENSG00000100079 ENSMUSG00000043501
UniProt P05162 Q9CQW5
RefSeq (mRNA) NM_006498 NM_025622
RefSeq (protein) NP_006489 NP_079898
Location (UCSC) Chr 22:
37.97 – 37.98 Mb
Chr 15:
78.85 – 78.86 Mb
PubMed search [1] [2]

Galectin-2 is a protein that in humans is encoded by the LGALS2 gene.[1][2][3]

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.[3]


  1. ^ Gitt MA, Barondes SH (Feb 1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry 30 (1): 82–9. doi:10.1021/bi00215a013. PMID 1988031. 
  2. ^ Sturm A, Lensch M, Andre S, Kaltner H, Wiedenmann B, Rosewicz S, Dignass AU, Gabius HJ (Sep 2004). "Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation". J Immunol 173 (6): 3825–37. doi:10.4049/jimmunol.173.6.3825. PMID 15356130. 
  3. ^ a b "Entrez Gene: LGALS2 lectin, galactoside-binding, soluble, 2". 

Further reading[edit]