LGALS2

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Lectin, galactoside-binding, soluble, 2
Protein LGALS2 PDB 1hlc.png
PDB rendering based on 1hlc.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LGALS2 ; HL14
External IDs OMIM150571 MGI895068 HomoloGene4741 ChEMBL: 5977 GeneCards: LGALS2 Gene
RNA expression pattern
PBB GE LGALS2 208450 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3957 107753
Ensembl ENSG00000100079 ENSMUSG00000043501
UniProt P05162 Q9CQW5
RefSeq (mRNA) NM_006498 NM_025622
RefSeq (protein) NP_006489 NP_079898
Location (UCSC) Chr 22:
37.97 – 37.98 Mb
Chr 15:
78.85 – 78.86 Mb
PubMed search [1] [2]

Galectin-2 is a protein that in humans is encoded by the LGALS2 gene.[1][2][3]

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.[3]

References[edit]

  1. ^ Gitt MA, Barondes SH (Feb 1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry 30 (1): 82–9. doi:10.1021/bi00215a013. PMID 1988031. 
  2. ^ Sturm A, Lensch M, Andre S, Kaltner H, Wiedenmann B, Rosewicz S, Dignass AU, Gabius HJ (Sep 2004). "Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation". J Immunol 173 (6): 3825–37. doi:10.4049/jimmunol.173.6.3825. PMID 15356130. 
  3. ^ a b "Entrez Gene: LGALS2 lectin, galactoside-binding, soluble, 2". 

Further reading[edit]