LGALS4

Lectin, galactoside-binding, soluble, 4
PDB rendering based on 1x50.
Available structures PDB 1X50
Identifiers
Symbols	LGALS4; GAL4; L36LBP
External IDs	OMIM: 602518 MGI: 107536 HomoloGene: 21239 GeneCards: LGALS4 Gene
Gene Ontology Molecular function • sugar binding Cellular component • cytosol • plasma membrane Biological process • cell adhesion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3960	16855
Ensembl	ENSG00000171747	ENSMUSG00000053964
UniProt	P56470	Q8K419
RefSeq (mRNA)	NM_006149.3	NM_010706.2
RefSeq (protein)	NP_006140.1	NP_034836.1
Location (UCSC)	Chr 19: 39.29 – 39.3 Mb	Chr 7: 29.62 – 29.63 Mb
PubMed search	[1]	[2]

Galectin-4 is a protein that in humans is encoded by the LGALS4 gene.

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer. The 323-amino acid LGALS4 protein contains 2 homologous, approximately 150-amino acid carbohydrate recognition domains and all amino acids typically conserved in galectins.

Further reading

• Huflejt ME, Jordan ET, Gitt MA, et al. (1997). "Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion.". J. Biol. Chem. 272 (22): 14294–303. doi:10.1074/jbc.272.22.14294. PMID 9162064. 
• Rechreche H, Mallo GV, Montalto G, et al. (1997). "Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer.". Eur. J. Biochem. 248 (1): 225–30. doi:10.1111/j.1432-1033.1997.00225.x. PMID 9310382. 
• Ideo H, Seko A, Ohkura T, et al. (2002). "High-affinity binding of recombinant human galectin-4 to SO(3)(-)-->3Galbeta1-->3GalNAc pyranoside.". Glycobiology 12 (3): 199–208. doi:10.1093/glycob/12.3.199. PMID 11971864. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ideo H, Seko A, Yamashita K (2005). "Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells.". J. Biol. Chem. 280 (6): 4730–7. doi:10.1074/jbc.M410362200. PMID 15546874. 
• Delacour D, Gouyer V, Zanetta JP, et al. (2005). "Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells.". J. Cell Biol. 169 (3): 491–501. doi:10.1083/jcb.200407073. PMC 2171948. PMID 15883199. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2171948. 
• Stowell SR, Karmakar S, Stowell CJ, et al. (2007). "Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.". Blood 109 (1): 219–27. doi:10.1182/blood-2006-03-007153. PMC 1785076. PMID 16940423. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1785076. 
• Ideo H, Seko A, Yamashita K (2007). "Recognition mechanism of galectin-4 for cholesterol 3-sulfate.". J. Biol. Chem. 282 (29): 21081–9. doi:10.1074/jbc.M703770200. PMID 17545668.