LGR4

Leucine-rich repeat containing G protein-coupled receptor 4
Identifiers
Symbols	LGR4; GPR48
External IDs	OMIM: 606666 MGI: 1891468 HomoloGene: 10226 IUPHAR: LGR4 GeneCards: LGR4 Gene
Gene Ontology Molecular function • signal transducer activity • receptor activity • G-protein coupled receptor activity • protein-hormone receptor activity Cellular component • plasma membrane • integral to membrane Biological process • G-protein coupled receptor signaling pathway • male genitalia development • tube morphogenesis • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • epithelial cell proliferation • canonical Wnt receptor signaling pathway involved in metanephric kidney development • cell differentiation involved in metanephros development • metanephric glomerulus development • metanephric nephron tubule morphogenesis • positive regulation of branching involved in ureteric bud morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55366	107515
Ensembl	ENSG00000205213	ENSMUSG00000050199
UniProt	Q9BXB1	A2ARI4
RefSeq (mRNA)	NM_018490.2	NM_172671.2
RefSeq (protein)	NP_060960.2	NP_766259.2
Location (UCSC)	Chr 11: 27.39 – 27.49 Mb	Chr 2: 109.76 – 109.85 Mb
PubMed search	[1]	[2]

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Further reading

• Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958. 
• Loh ED, Broussard SR, Kolakowski LF (2001). "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. doi:10.1006/bbrc.2001.4625. PMID 11401528. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.