LGR5
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| Leucine-rich repeat containing G protein-coupled receptor 5 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LGR5; FEX; GPR49; GPR67; GRP49; HG38 | ||||||||||||
| External IDs | OMIM: 606667 MGI: 1341817 HomoloGene: 20807 IUPHAR: LGR5 GeneCards: LGR5 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8549 | 14160 | |||||||||||
| Ensembl | ENSG00000139292 | ENSMUSG00000020140 | |||||||||||
| UniProt | O75473 | Q9Z1P4 | |||||||||||
| RefSeq (mRNA) | NM_003667.2 | NM_010195.2 | |||||||||||
| RefSeq (protein) | NP_003658.1 | NP_034325.2 | |||||||||||
| Location (UCSC) | Chr 12: 71.83 – 71.98 Mb |
Chr 10: 114.89 – 115.02 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Leucine-rich repeat-containing G-protein coupled receptor 5 is a protein that in humans is encoded by the LGR5 gene.[1][2] It is also known as GPR49.
LGR5 was recently shown to be present in mouse hair follicles and intestinal epithelium and can potentially be used to regrow hair in mice and epithelial cell renewing.
[edit] References
- ^ McDonald T, Wang R, Bailey W, Xie G, Chen F, Caskey CT, Liu Q (Jul 1998). "Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily". Biochem Biophys Res Commun 247 (2): 266–70. doi:10.1006/bbrc.1998.8774. PMID 9642114.
- ^ "Entrez Gene: LGR5 leucine-rich repeat-containing G protein-coupled receptor 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8549.
[edit] Further reading
- Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region.". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958.
- Hsu SY, Kudo M, Chen T et al (2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol. Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Yamamoto Y, Sakamoto M, Fujii G et al (2003). "Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations". Hepatology 37 (3): 528–33. doi:10.1053/jhep.2003.50029. PMID 12601349.
- McClanahan T, Koseoglu S, Smith K et al (2007). "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors". Cancer Biol. Ther. 5 (4): 419–26. PMID 16575208.
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