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Leucine-rich repeat containing G protein-coupled receptor 6
Symbols LGR6 ; GPCR; VTS20631
External IDs OMIM606653 MGI2441805 HomoloGene49680 IUPHAR: 149 GeneCards: LGR6 Gene
RNA expression pattern
PBB GE LGR6 gnf1h10211 at tn.png
More reference expression data
Species Human Mouse
Entrez 59352 329252
Ensembl ENSG00000133067 ENSMUSG00000042793
UniProt Q9HBX8 Q3UVD5
RefSeq (mRNA) NM_001017403 NM_001033409
RefSeq (protein) NP_001017403 NP_001028581
Location (UCSC) Chr 1:
202.16 – 202.29 Mb
Chr 1:
134.99 – 135.11 Mb
PubMed search [1] [2]

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene.[1][2]

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.[2]


  1. ^ Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol Endocrinol 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549. 
  2. ^ a b "Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.