LGR6

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Leucine-rich repeat containing G protein-coupled receptor 6
Identifiers
Symbols LGR6 ; GPCR; VTS20631
External IDs OMIM606653 MGI2441805 HomoloGene49680 IUPHAR: LGR6 GeneCards: LGR6 Gene
RNA expression pattern
PBB GE LGR6 gnf1h10211 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 59352 329252
Ensembl ENSG00000133067 ENSMUSG00000042793
UniProt Q9HBX8 Q3UVD5
RefSeq (mRNA) NM_001017403 NM_001033409
RefSeq (protein) NP_001017403 NP_001028581
Location (UCSC) Chr 1:
202.16 – 202.29 Mb
Chr 1:
134.99 – 135.11 Mb
PubMed search [1] [2]

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene.[1][2]

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.[2]

References[edit]

  1. ^ Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol Endocrinol 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549. 
  2. ^ a b "Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.