LGTN

Eukaryotic translation initiation factor 2D
Identifiers
Symbols	EIF2D; HCA56; LGTN
External IDs	OMIM: 613709 MGI: 109342 HomoloGene: 38244 GeneCards: EIF2D Gene
Gene Ontology Molecular function • RNA binding • translation initiation factor activity • receptor activity • protein binding Cellular component • cytoplasm Biological process • translational initiation • intracellular protein transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1939	16865
Ensembl	ENSG00000143486	ENSMUSG00000026427
UniProt	P41214	Q61211
RefSeq (mRNA)	NM_001201478.1	XM_976282
RefSeq (protein)	NP_001188407.1	XP_981376
Location (UCSC)	Chr 1: 206.74 – 206.79 Mb	Chr 1: 133.05 – 133.08 Mb
PubMed search	[1]	[2]

Ligatin is a protein that in humans is encoded by the LGTN gene.

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.

Further reading

• Jakoi ER, Ross PE, Ping Ting-Beall H, et al. (1987). "Ligatin: a peripheral membrane protein with covalently bound palmitic acid". J. Biol. Chem. 262 (3): 1300–4. PMID 3805022. 
• Gaston SM, Marchase RB, Jakoi ER (1982). "Brain ligatin: a membrane lectin that binds acetylcholinesterase". J. Cell. Biochem. 18 (4): 447–59. doi:10.1002/jcb.1982.240180406. PMID 7085778. 
• Marchase RB, Koro LA, Kelly CM, McClay DR (1982). "A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion". J. Cell. Biochem. 18 (4): 461–8. doi:10.1002/jcb.1982.240180407. PMID 7085779. 
• Jakoi ER, Kempe K, Gaston SM (1982). "Ligatin binds phosphohexose residues on acidic hydrolases". Journal of supramolecular structure and cellular biochemistry 16 (2): 139–53. doi:10.1002/jsscb.1981.380160205. PMID 7299841. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. PMID 12097419. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.