LHFPL2
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| Lipoma HMGIC fusion partner-like 2 | |||||||||
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| Identifiers | |||||||||
| Symbols | LHFPL2; DKFZp781E0375; KIAA0206 | ||||||||
| External IDs | OMIM: 609718 MGI: 2145236 HomoloGene: 4222 GeneCards: LHFPL2 Gene | ||||||||
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| RNA expression pattern | |||||||||
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| More reference expression data | |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 10184 | 218454 | |||||||
| Ensembl | ENSG00000145685 | ENSMUSG00000045312 | |||||||
| UniProt | Q6ZUX7 | Q8BGA2 | |||||||
| RefSeq (mRNA) | NM_005779.2 | NM_172589.2 | |||||||
| RefSeq (protein) | NP_005770.1 | NP_766177.1 | |||||||
| Location (UCSC) | Chr 5: 77.78 – 78.07 Mb |
Chr 13: 94.83 – 94.97 Mb |
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| PubMed search | [1] | [2] | |||||||
Lipoma HMGIC fusion partner-like 2 protein is a protein that in humans is encoded by the LHFPL2 gene.[1][2]
This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.[2]
[edit] References
- ^ Petit MM, Schoenmakers EF, Huysmans C, Geurts JM, Mandahl N, Van de Ven WJ (Aug 1999). "LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes". Genomics 57 (3): 438–41. doi:10.1006/geno.1999.5778. PMID 10329012.
- ^ a b "Entrez Gene: LHFPL2 lipoma HMGIC fusion partner-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10184.
[edit] Further reading
- Kimura K, Wakamatsu A, Suzuki Y et al (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Longo-Guess CM, Gagnon LH, Cook SA et al (2005). "A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice". Proc. Natl. Acad. Sci. U.S.A. 102 (22): 7894–9. doi:10.1073/pnas.0500760102. PMC 1142366. PMID 15905332. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1142366.
- Brandenberger R, Wei H, Zhang S et al (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Nagase T, Seki N, Ishikawa K et al (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
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