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LIM homeobox 2
Protein LHX2 PDB 2dmq.png
PDB rendering based on 2dmq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LHX2 ; LH2; hLhx2
External IDs OMIM603759 MGI96785 HomoloGene55848 GeneCards: LHX2 Gene
RNA expression pattern
PBB GE LHX2 206140 at tn.png
PBB GE LHX2 211219 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9355 16870
Ensembl ENSG00000106689 ENSMUSG00000000247
UniProt P50458 Q9Z0S2
RefSeq (mRNA) NM_004789 NM_001290646
RefSeq (protein) NP_004780 NP_001277575
Location (UCSC) Chr 9:
126.76 – 126.8 Mb
Chr 2:
38.34 – 38.37 Mb
PubMed search [1] [2]

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[1][2][3]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[3]


LHX2 has been shown to interact with CITED2.[4]


  1. ^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (Jul 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene 12 (6): 1205–12. PMID 8649822. 
  2. ^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (Apr 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A 96 (5): 2165–70. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612. 
  3. ^ a b "Entrez Gene: LHX2 LIM homeobox 2". 
  4. ^ Glenn, D J; Maurer R A (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. (UNITED STATES) 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900. 

Further reading[edit]