LILRB1

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
	; PDB rendering based on 1g0x.
Available structures
PDB	1G0X, 1P7Q, 1UFU, 1UGN, 1VDG, 2DYP, 2GW5, 3D2U
Identifiers
Symbols	LILRB1; CD85; CD85J; FLJ37515; ILT2; LIR-1; LIR1; MIR-7; MIR7
External IDs	OMIM: 604811 HomoloGene: 88463 GeneCards: LILRB1 Gene
Gene Ontology
Molecular function	• receptor activity; • protein phosphatase 1 binding;
Cellular component	• plasma membrane; • integral to membrane;
Biological process	• response to virus; • regulation of immune response;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.^[1]^[2]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[3]

[edit] See also

Cluster of differentiation

[edit] References

^ Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Sep 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity 7 (2): 273–82. doi:10.1016/S1074-7613(00)80529-4. PMID 9285411.
^ Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M (Dec 1997). "A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells". J Exp Med 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199153.
^ "Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10859.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hirohashi N, Nakao M, Kubo K et al (1994). "A novel antigen (H47 Ag) on human lymphocytes involved in T cell activation". Cell. Immunol. 152 (2): 371–82. doi:10.1006/cimm.1993.1298. PMID 8258145.
Samaridis J, Colonna M (1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur. J. Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
Wagtmann N, Rojo S, Eichler E et al (1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors". Curr. Biol. 7 (8): 615–8. doi:10.1016/S0960-9822(06)00263-6. PMID 9259559.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Fanger NA, Cosman D, Peterson L et al (1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
Navarro F, Llano M, Bellón T et al (1999). "The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells". Eur. J. Immunol. 29 (1): 277–83. doi:10.1002/(SICI)1521-4141(199901)29:01<277::AID-IMMU277>3.0.CO;2-4. PMID 9933109.
Chapman TL, Heikeman AP, Bjorkman PJ (2000). "The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18". Immunity 11 (5): 603–13. doi:10.1016/S1074-7613(00)80135-1. PMID 10591185.
Liu WR, Kim J, Nwankwo C et al (2000). "Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4". Immunogenetics 51 (8–9): 659–69. doi:10.1007/s002510000183. PMID 10941837.
Chapman TL, Heikema AP, West AP, Bjorkman PJ (2001). "Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2)". Immunity 13 (5): 727–36. doi:10.1016/S1074-7613(00)00071-6. PMID 11114384.
Lepin EJ, Bastin JM, Allan DS et al (2001). "Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors". Eur. J. Immunol. 30 (12): 3552–61. doi:10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L. PMID 11169396.
Young NT, Canavez F, Uhrberg M et al (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530.
Saverino D, Merlo A, Bruno S et al (2002). "Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells". J. Immunol. 168 (1): 207–15. PMID 11751964.
Bellón T, Kitzig F, Sayós J, López-Botet M (2002). "Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor". J. Immunol. 168 (7): 3351–9. PMID 11907092.
Nikolova M, Musette P, Bagot M et al (2002). "Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling". Blood 100 (3): 1019–25. doi:10.1182/blood-2001-12-0303. PMID 12130517.
Willcox BE, Thomas LM, Chapman TL et al (2003). "Crystal structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18". BMC Struct. Biol. 2: 6. doi:10.1186/1472-6807-2-6. PMC 130215. PMID 12390682. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=130215.
Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Achdout H, Arnon TI, Markel G et al (2003). "Enhanced recognition of human NK receptors after influenza virus infection". J. Immunol. 171 (2): 915–23. PMID 12847262.