LILRB2

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Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Protein LILRB2 PDB 2dyp.png
PDB rendering based on 2dyp.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LILRB2 ; CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10; MIR10
External IDs OMIM604815 HomoloGene136797 GeneCards: LILRB2 Gene
Orthologs
Species Human Mouse
Entrez 10288 n/a
Ensembl ENSG00000131042 n/a
UniProt Q8N423 n/a
RefSeq (mRNA) NM_001080978 n/a
RefSeq (protein) NP_001074447 n/a
Location (UCSC) Chr 19:
54.78 – 54.79 Mb
n/a
PubMed search [1] n/a

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.[1][2][3]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

Interactions[edit]

LILRB2 has been shown to interact with PTPN6.[4][5]

See also[edit]

References[edit]

  1. ^ Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (Jun 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". J Exp Med 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699. 
  2. ^ Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. 
  3. ^ a b "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2". 
  4. ^ Fanger, N A; Cosman D; Peterson L; Braddy S C; Maliszewski C R; Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. (GERMANY) 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. ISSN 0014-2980. PMID 9842885. 
  5. ^ Colonna, M; Samaridis J; Cella M; Angman L; Allen R L; O'Callaghan C A; Dunbar R; Ogg G S; Cerundolo V; Rolink A (Apr 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. (UNITED STATES) 160 (7): 3096–100. ISSN 0022-1767. PMID 9531263. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.