LIMK2

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LIM domain kinase 2
Protein LIMK2 PDB 1x6a.png
PDB rendering based on 1x6a.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol LIMK2
External IDs OMIM601988 MGI1197517 HomoloGene55911 IUPHAR: 2055 ChEMBL: 5932 GeneCards: LIMK2 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE LIMK2 202193 at tn.png
PBB GE LIMK2 210582 s at tn.png
PBB GE LIMK2 217475 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3985 16886
Ensembl ENSG00000182541 ENSMUSG00000020451
UniProt P53671 O54785
RefSeq (mRNA) NM_001031801 NM_001034030
RefSeq (protein) NP_001026971 NP_001029202
Location (UCSC) Chr 22:
31.61 – 31.68 Mb
Chr 11:
3.34 – 3.41 Mb
PubMed search [1] [2]

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.[1][2][3]

Function[edit]

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.[3]

References[edit]

  1. ^ Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S et al. (Dec 1995). "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs". The Journal of Biological Chemistry 270 (52): 31321–30. doi:10.1074/jbc.270.52.31321. PMID 8537403. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ a b "Entrez Gene: LIMK2 LIM domain kinase 2". 

Further reading[edit]

External links[edit]