LIMK2

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LIM domain kinase 2
Protein LIMK2 PDB 1x6a.png
PDB rendering based on 1x6a.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol LIMK2
External IDs OMIM601988 MGI1197517 HomoloGene55911 ChEMBL: 5932 GeneCards: LIMK2 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE LIMK2 202193 at tn.png
PBB GE LIMK2 210582 s at tn.png
PBB GE LIMK2 217475 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3985 16886
Ensembl ENSG00000182541 ENSMUSG00000020451
UniProt P53671 O54785
RefSeq (mRNA) NM_001031801 NM_001034030
RefSeq (protein) NP_001026971 NP_001029202
Location (UCSC) Chr 22:
31.61 – 31.68 Mb
Chr 11:
3.34 – 3.41 Mb
PubMed search [1] [2]

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.[1][2][3]

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.[3]

References[edit]

  1. ^ Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S, Hirai M, Mizuno K (Feb 1996). "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs". J Biol Chem 270 (52): 31321–30. doi:10.1074/jbc.270.52.31321. PMID 8537403. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ a b "Entrez Gene: LIMK2 LIM domain kinase 2". 

Further reading[edit]


External links[edit]