LIMS1

LIM and senescent cell antigen-like domains 1
PDB rendering based on 1g47.
Available structures PDB 1G47, 1NYP, 1U5S, 2COR, 2D8X, 2KBX, 3F6Q
Identifiers
Symbols	LIMS1; PINCH; PINCH-1; PINCH1
External IDs	OMIM: 602567 HomoloGene: 123779 GeneCards: LIMS1 Gene
Gene Ontology Molecular function • protein binding • zinc ion binding • metal ion binding Cellular component • cytosol • plasma membrane • focal adhesion • focal adhesion • cell junction • perinuclear region of cytoplasm Biological process • cell-matrix adhesion • establishment or maintenance of cell polarity • cell aging • cell-cell adhesion • cell junction assembly • chordate embryonic development • negative regulation of transcription, DNA-dependent • cellular response to transforming growth factor beta stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3987	n/a
Ensembl	ENSG00000169756	n/a
UniProt	P48059	n/a
RefSeq (mRNA)	NM_001193482.1	n/a
RefSeq (protein)	NP_001180411.1	n/a
Location (UCSC)	Chr 2: 109.15 – 109.3 Mb	n/a
PubMed search	[1]	n/a

LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene.

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.

Interactions

LIMS1 has been shown to interact with Integrin-linked kinase and NCK2.

Further reading

• Tu Y, Li F, Wu C (1999). "Nck-2, a Novel Src Homology2/3-containing Adaptor Protein That Interacts with the LIM-only Protein PINCH and Components of Growth Factor Receptor Kinase-signaling Pathways". Mol. Biol. Cell 9 (12): 3367–82. PMC 25640. PMID 9843575. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25640. 
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. 
• Velyvis A, Yang Y, Wu C, Qin J (2001). "Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain". J. Biol. Chem. 276 (7): 4932–9. doi:10.1074/jbc.M007632200. PMID 11078733. 
• Tu Y, Huang Y, Zhang Y, et al. (2001). "A New Focal Adhesion Protein That Interacts with Integrin-Linked Kinase and Regulates Cell Adhesion and Spreading". J. Cell Biol. 153 (3): 585–98. doi:10.1083/jcb.153.3.585. PMC 2190577. PMID 11331308. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2190577. 
• Zhang Y, Chen K, Tu Y, et al. (2003). "Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites". J. Cell. Sci. 115 (Pt 24): 4777–86. doi:10.1242/jcs.00166. PMID 12432066. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Campana WM, Myers RR, Rearden A (2003). "Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury". Glia 41 (3): 213–23. doi:10.1002/glia.10138. PMID 12528177. 
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
• Velyvis A, Vaynberg J, Yang Y, et al. (2003). "Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling". Nat. Struct. Biol. 10 (7): 558–64. doi:10.1038/nsb938. PMID 12794636. 
• Fukuda T, Chen K, Shi X, Wu C (2004). "PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival". J. Biol. Chem. 278 (51): 51324–33. doi:10.1074/jbc.M309122200. PMID 14551191. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Bock-Marquette I, Saxena A, White MD, et al. (2004). "Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair". Nature 432 (7016): 466–72. doi:10.1038/nature03000. PMID 15565145. 
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. 
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Dougherty GW, Chopp T, Qi SM, Cutler ML (2005). "The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions". Exp. Cell Res. 306 (1): 168–79. doi:10.1016/j.yexcr.2005.01.025. PMID 15878342. 
• Xu Z, Fukuda T, Li Y, et al. (2005). "Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival". J. Biol. Chem. 280 (30): 27631–7. doi:10.1074/jbc.M504189200. PMID 15941716. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.