From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lin-7 homolog B (C. elegans)
Protein LIN7B PDB 1y74.png
PDB rendering based on 1y74.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LIN7B ; LIN-7B; MALS-2; MALS2; VELI2
External IDs OMIM612331 MGI1330858 HomoloGene22648 GeneCards: LIN7B Gene
RNA expression pattern
PBB GE LIN7B 219760 at tn.png
More reference expression data
Species Human Mouse
Entrez 64130 22342
Ensembl ENSG00000104863 ENSMUSG00000003872
UniProt Q9HAP6 O88951
RefSeq (mRNA) NM_022165 NM_011698
RefSeq (protein) NP_071448 NP_035828
Location (UCSC) Chr 19:
49.62 – 49.62 Mb
Chr 7:
45.37 – 45.37 Mb
PubMed search [1] [2]

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.[1][2]


LIN7B has been shown to interact with KCNJ4,[3] GRIN2B,[1] KCNJ12[4][5] and ACCN3.[6]


  1. ^ a b Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci 19 (11): 4189–99. PMID 10341223. 
  2. ^ "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)". 
  3. ^ Olsen, Olav; Liu Hui; Wade James B; Merot Jean; Welling Paul A (Jan 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. (United States) 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. ISSN 0363-6143. PMID 11742811. 
  4. ^ Leonoudakis, Dmitri; Conti Lisa R; Anderson Scott; Radeke Carolyn M; McGuire Leah M M; Adams Marvin E; Froehner Stanley C; Yates John R; Vandenberg Carol A (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. (United States) 279 (21): 22331–46. doi:10.1074/jbc.M400285200. ISSN 0021-9258. PMID 15024025. 
  5. ^ Leonoudakis, Dmitri; Conti Lisa R; Radeke Carolyn M; McGuire Leah M M; Vandenberg Carol A (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. (United States) 279 (18): 19051–63. doi:10.1074/jbc.M400284200. ISSN 0021-9258. PMID 14960569. 
  6. ^ Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. (United States) 279 (45): 46962–8. doi:10.1074/jbc.M405874200. ISSN 0021-9258. PMID 15317815. 

Further reading[edit]