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Leucine rich repeat and Ig domain containing 1
Protein LINGO1 PDB 2id5.png
PDB rendering based on 2id5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LINGO1 ; LERN1; LRRN6A; UNQ201
External IDs OMIM609791 MGI1915522 HomoloGene41891 GeneCards: LINGO1 Gene
Species Human Mouse
Entrez 84894 235402
Ensembl ENSG00000169783 ENSMUSG00000049556
UniProt Q96FE5 Q9D1T0
RefSeq (mRNA) NM_032808 NM_181074
RefSeq (protein) NP_116197 NP_851419
Location (UCSC) Chr 15:
77.91 – 78.11 Mb
Chr 9:
56.62 – 56.69 Mb
PubMed search [1] [2]

Leucine rich repeat and Ig domain containing 1 also known as LINGO-1 is a protein which in humans is encoded by the LINGO1 gene.[1][2]


LINGO-1 contains an N-terminal leucine-rich repeat (LRR) domain, followed by 9 typical LRR domains, C-terminal LRR domain, an IgC2 domain, a transmembrane domain, and a cytoplasmic tail.[2][3]

LINGO-1 interacts with the Nogo receptor.[3]


LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system.[3] LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require 75 or NgR1.


  1. ^ "Entrez Gene: LINGO1 leucine rich repeat and Ig domain containing 1". 
  2. ^ a b Carim-Todd L, Escarceller M, Estivill X, Sumoy L (December 2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". Eur. J. Neurosci. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891. 
  3. ^ a b c Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T, Cate RL, McCoy JM, Pepinsky RB (March 2004). "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex". Nat. Neurosci. 7 (3): 221–8. doi:10.1038/nn1188. PMID 14966521. 

Further reading[edit]