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Leucine rich repeat and Ig domain containing 1
Protein LINGO1 PDB 2id5.png
PDB rendering based on 2id5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LINGO1 ; LERN1; LRRN6A; UNQ201
External IDs OMIM609791 MGI1915522 HomoloGene41891 GeneCards: LINGO1 Gene
Species Human Mouse
Entrez 84894 235402
Ensembl ENSG00000169783 ENSMUSG00000049556
UniProt Q96FE5 Q9D1T0
RefSeq (mRNA) NM_001301186 NM_181074
RefSeq (protein) NP_001288115 NP_851419
Location (UCSC) Chr 15:
77.91 – 78.11 Mb
Chr 9:
56.62 – 56.69 Mb
PubMed search [1] [2]

Leucine rich repeat and Ig domain containing 1 also known as LINGO-1 is a protein which in humans is encoded by the LINGO1 gene.[1][2]


LINGO-1 contains an N-terminal leucine-rich repeat (LRR) domain, followed by 9 typical LRR domains, C-terminal LRR domain, an IgC2 domain, a transmembrane domain, and a cytoplasmic tail.[2][3]

LINGO-1 interacts with the Nogo receptor.[3]


LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system.[3] LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require p75 or NgR1.

Recent post mortem studies have evidenced an increase in LINGO1 in the cerebellum of people with essential tremor.[4][5]


  1. ^ "Entrez Gene: LINGO1 leucine rich repeat and Ig domain containing 1". 
  2. ^ a b Carim-Todd L, Escarceller M, Estivill X, Sumoy L (December 2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". Eur. J. Neurosci. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891. 
  3. ^ a b c Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J et al. (March 2004). "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex". Nat. Neurosci. 7 (3): 221–8. doi:10.1038/nn1188. PMID 14966521. 
  4. ^ Delay C, Tremblay C, Brochu E, Paris-Robidas S, Emond V, Rajput AH et al. (2014). "Increased LINGO1 in the cerebellum of essential tremor patients". Mov Disord. doi:10.1002/mds.25819. PMID 24531928. 
  5. ^ Kuo SH, Tang G, Louis ED, Ma K, Babji R, Balatbat M et al. (2013). "Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau". Acta Neuropathol 125 (6): 879–89. doi:10.1007/s00401-013-1108-7. PMID 23543187. 

Further reading[edit]