LIPH (gene)

LIPH
Identifiers
Aliases	LIPH, AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H
External IDs	OMIM: 607365 MGI: 2388029 HomoloGene: 71802 GeneCards: LIPH
Gene location (Human) Chr. Chromosome 3 (human) Band 3q27.2 Start 185,506,262 bp End 185,552,588 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B1|16 12.95 cM Start 21,772,567 bp End 21,814,413 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum pancreatic ductal cell islet of Langerhans amniotic fluid palpebral conjunctiva gallbladder minor salivary glands right lung body of stomach upper lobe of left lung Top expressed in epithelium of stomach duodenum otolith organ ileum utricle right lung lobe left colon jejunum conjunctival fornix left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding carboxylic ester hydrolase activity hydrolase activity phospholipase activity lipase activity Cellular component extracellular region plasma membrane membrane extracellular space Biological process lipid catabolic process lipid metabolism phosphatidic acid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200879 239759 Ensembl ENSG00000163898 ENSMUSG00000044626 UniProt Q8WWY8 Q8CIV3 RefSeq (mRNA) NM_139248 NM_001083894 NM_001289581 NM_001289582 NM_153404 RefSeq (protein) NP_640341 NP_001077363 NP_001276510 NP_001276511 NP_700453 Location (UCSC) Chr 3: 185.51 – 185.55 Mb Chr 16: 21.77 – 21.81 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Lipase member H is an enzyme that in humans is encoded by the LIPH gene.

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wen XY, Hegele RA, Wang J, et al. (2004). "Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans". Hum. Mol. Genet. 12 (10): 1131–43. doi:10.1093/hmg/ddg124. PMID 12719377.
• Hiramatsu T, Sonoda H, Takanezawa Y, et al. (2004). "Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta". J. Biol. Chem. 278 (49): 49438–47. doi:10.1074/jbc.M213018200. PMID 12963729.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Aslam M, Chahrour MH, Razzaq A, et al. (2005). "A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33–q27.3". J. Med. Genet. 41 (11): 849–52. doi:10.1136/jmg.2004.019729. PMC 1735610. PMID 15520410.
• Kazantseva A, Goltsov A, Zinchenko R, et al. (2006). "Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH". Science. 314 (5801): 982–5. Bibcode:2006Sci...314..982K. doi:10.1126/science.1133276. PMID 17095700. S2CID 17395376.
• Ali G, Chishti MS, Raza SI, et al. (2007). "A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis". Hum. Genet. 121 (3–4): 319–25. doi:10.1007/s00439-007-0344-0. PMID 17333281. S2CID 9640640.