LMAN1

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Lectin, mannose-binding, 1
Protein LMAN1 PDB 1r1z.png
PDB rendering based on 1r1z.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LMAN1 ; ERGIC-53; ERGIC53; F5F8D; FMFD1; MCFD1; MR60; gp58
External IDs OMIM601567 MGI1917611 HomoloGene4070 GeneCards: LMAN1 Gene
RNA expression pattern
PBB GE LMAN1 203293 s at tn.png
PBB GE LMAN1 203294 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3998 70361
Ensembl ENSG00000074695 ENSMUSG00000041891
UniProt P49257 Q9D0F3
RefSeq (mRNA) NM_005570 NM_001172062
RefSeq (protein) NP_005561 NP_001165533
Location (UCSC) Chr 18:
57 – 57.03 Mb
Chr 18:
65.98 – 66.02 Mb
PubMed search [1] [2]

Protein ERGIC-53 also known as ER-Golgi intermediate compartment 53 kDa protein or lectin mannose-binding 1 is a protein that in humans is encoded by the LMAN1 gene.[1][2][3]

Function[edit]

ERGIC-53 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. Also named LMAN1, the protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined deficiency of factor V-factor VIII, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.[3] MCFD2 is the second gene that leads to combined deficiency of factor V-factor VIII.[4] ERGIC-53 and MCFD2 form a protein complex and serve as a cargo receptor to transport FV and FVIII from the ER to the Golgi body.[5]

Clinical significance[edit]

LMAN1 mutational inactivation is a frequent and early event potentially contributing to colorectal tumorigenesis.[6]

References[edit]

  1. ^ Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli MJ, Hauri HP, Ciavarella N, Kaufman RJ, Ginsburg D (May 1998). "Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII". Cell 93 (1): 61–70. doi:10.1016/S0092-8674(00)81146-0. PMID 9546392. 
  2. ^ Arar C, Mignon C, Mattei M, Monsigny M, Roche A, Legrand A (Feb 1997). "Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization". Mamm Genome 7 (10): 791–2. doi:10.1007/s003359900238. PMID 8854877. 
  3. ^ a b "Entrez Gene: LMAN1 lectin, mannose-binding, 1". 
  4. ^ Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D (May 2003). "Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex". Nat Genet 34 (2): 220–5. doi:10.1038/ng1153. PMID 12717434. 
  5. ^ Zhang B, Kaufman RJ, Ginsburg D (2005). "LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway". J. Biol. Chem. 280 (27): 25881–6. doi:10.1074/jbc.M502160200. PMID 15886209. 
  6. ^ Roeckel N, Woerner SM, Kloor M, Yuan YP, Patsos G, Gromes R, Kopitz J, Gebert J (January 2009). "High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability". Cancer Res. 69 (1): 292–9. doi:10.1158/0008-5472.CAN-08-3314. PMID 19118014. 


Further reading[edit]