LMNB1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lamin B1
Protein LMNB1 PDB 2KPW.png
Rendering based on PDB 2KPW.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LMNB1 ; ADLD; LMN; LMN2; LMNB
External IDs OMIM150340 MGI96795 HomoloGene55912 GeneCards: LMNB1 Gene
RNA expression pattern
PBB GE LMNB1 203276 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4001 16906
Ensembl ENSG00000113368 ENSMUSG00000024590
UniProt P20700 P14733
RefSeq (mRNA) NM_001198557 NM_010721
RefSeq (protein) NP_001185486 NP_034851
Location (UCSC) Chr 5:
126.11 – 126.17 Mb
Chr 18:
56.71 – 56.75 Mb
PubMed search [1] [2]

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene.[1][2][3]

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.[3] Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor.

Interactions[edit]

LMNB1 has been shown to interact with Thymopoietin.[4][5]

See also[edit]

References[edit]

  1. ^ Lin F, Worman HJ (Nov 1995). "Structural organization of the human gene (LMNB1) encoding nuclear lamin B1". Genomics 27 (2): 230–6. doi:10.1006/geno.1995.1036. PMID 7557986. 
  2. ^ Wydner KL, McNeil JA, Lin F, Worman HJ, Lawrence JB (Feb 1997). "Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization". Genomics 32 (3): 474–8. doi:10.1006/geno.1996.0146. PMID 8838815. 
  3. ^ a b "Entrez Gene: LMNB1 lamin B1". 
  4. ^ Furukawa, K; Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". Eur. J. Biochem. (GERMANY) 251 (3): 729–33. doi:10.1046/j.1432-1327.1998.2510729.x. ISSN 0014-2956. PMID 9490046. 
  5. ^ Foisner, R; Gerace L (Jul 1993). "Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation". Cell (UNITED STATES) 73 (7): 1267–79. doi:10.1016/0092-8674(93)90355-T. ISSN 0092-8674. PMID 8324822. 

Further reading[edit]