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LIM domain only 2 (rhombotin-like 1)
Protein LDB1 PDB 2XJY.png
Rendering based on PDB 2XJY.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LMO2 ; RBTN2; RBTNL1; RHOM2; TTG2
External IDs OMIM180385 MGI102811 HomoloGene4072 GeneCards: LMO2 Gene
RNA expression pattern
PBB GE LMO2 204249 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4005 16909
Ensembl ENSG00000135363 ENSMUSG00000032698
UniProt P25791 P25801
RefSeq (mRNA) NM_001142315 NM_001142335
RefSeq (protein) NP_001135787 NP_001135807
Location (UCSC) Chr 11:
33.88 – 33.91 Mb
Chr 2:
103.96 – 103.98 Mb
PubMed search [1] [2]

LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2. LMO2 is a protein which in humans is encoded by the LMO2 gene.[1]


LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis.[2] The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.

Clinical significance[edit]

The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number of T-cell acute lymphoblastic leukemia-specific translocations occur.[3]


LMO2 has been shown to interact with:


  1. ^ Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (1991). "The Rhombotin Family of Cysteine-Rich LIM-Domain Oncogenes: Distinct Members are Involved in T-Cell Translocations to Human Chromosomes 11p15 and 11p13". Proceedings of the National Academy of Sciences 88 (10): 4367–71. doi:10.1073/pnas.88.10.4367. PMC 51660. PMID 2034676. 
  2. ^ Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH (1994). "The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development". Cell 78 (1): 45–57. PMID 8033210. 
  3. ^ EntrezGene 4005
  4. ^ a b c Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH. "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. PMC 40846. PMID 7568177. 
  5. ^ Mao S, Neale GA, Goorha RM. "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. PMID 9129143. 
  6. ^ Bégay-Müller V, Ansieau S, Leutz A. "The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene". FEBS Lett. 521 (1-3): 36–8. PMID 12067721. 
  7. ^ Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R. "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. PMC 395422. PMID 7957052. 
  8. ^ Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH. "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. PMC 44657. PMID 8078932. 
  9. ^ Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T. "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974. 

Further reading[edit]