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LIM domain only 4
Protein LMO4 PDB 1rut.png
PDB rendering based on 1rut.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol LMO4
External IDs OMIM603129 MGI109360 HomoloGene4927 GeneCards: LMO4 Gene
RNA expression pattern
PBB GE LMO4 209205 s at tn.png
PBB GE LMO4 209204 at tn.png
More reference expression data
Species Human Mouse
Entrez 8543 16911
Ensembl ENSG00000143013 ENSMUSG00000028266
UniProt P61968 P61969
RefSeq (mRNA) NM_006769 NM_001161769
RefSeq (protein) NP_006760 NP_001155241
Location (UCSC) Chr 1:
87.79 – 87.81 Mb
Chr 3:
144.19 – 144.21 Mb
PubMed search [1] [2]

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.[1]

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.[1]


LMO4 has been shown to interact with LDB1,[2][3] RBBP8[2][4] and BRCA1.[2][4]


  1. ^ a b "Entrez Gene: LMO4 LIM domain only 4". 
  2. ^ a b c Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer (United States) 107 (1): 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972. 
  3. ^ Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. (England) 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068. PMID 12727888. 
  4. ^ a b Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. (United States) 277 (10): 7849–56. doi:10.1074/jbc.M110603200. ISSN 0021-9258. PMID 11751867. 

Further reading[edit]