The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
^Kesavapany, Sashi; Lau Kwok-Fai, Ackerley Steven, Banner Steven J, Shemilt Stephen J A, Cooper Jonathan D, Leigh P Nigel, Shaw Christopher E, McLoughlin Declan M, Miller Christopher C J (Jun. 2003). "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase". J. Neurosci. (United States) 23 (12): 4975–83. PMID12832520.
Eeles RA, Kote-Jarai Z, Giles GG, et al. (2008). "Multiple newly identified loci associated with prostate cancer susceptibility.". Nat. Genet.40 (3): 316–21. doi:10.1038/ng.90. PMID18264097.
Chibalina MV, Seaman MN, Miller CC, et al. (2008). "Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.". J. Cell. Sci.120 (Pt 24): 4278–88. doi:10.1242/jcs.014217. PMC2621362. PMID18029400.
Kesavapany S, Lau KF, Ackerley S, et al. (2003). "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.". J. Neurosci.23 (12): 4975–83. PMID12832520.
Wang H, Brautigan DL (2003). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.". J. Biol. Chem.277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID12393858.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res.6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID10470851.