LP-44

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LP-44
LP-44 structure.png
Systematic (IUPAC) name
4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide
Clinical data
Legal status ?
Identifiers
CAS number 824958-12-5 YesY
ATC code ?
PubChem CID 11224758
Chemical data
Formula C27H37N3OS 
Mol. mass 451.666 g/mol
 YesY (what is this?)  (verify)

LP-44 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor. While LP-44 is less selective than the related compound LP-12, it has been more widely used in research and has been used to show the complex role of 5-HT7 receptors in several aspects of brain function, including regulation of the sleep-wake cycle and roles in stress, learning and memory.[1][2][3][4]

See also[edit]

References[edit]

  1. ^ Monti JM, Leopoldo M, Jantos H (August 2008). "The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat". Behavioural Brain Research 191 (2): 184–9. doi:10.1016/j.bbr.2008.03.025. PMID 18466985. 
  2. ^ Xu Y, Zhang C, Wang R, Govindarajan SS, Barish PA, Vernon MM, Fu C, Acharya AP, Chen L, Boykin E, Yu J, Pan J, O'Donnell JM, Ogle WO (May 2011). "Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway". Neuroscience 182: 71–81. doi:10.1016/j.neuroscience.2011.02.042. PMID 21371532. 
  3. ^ Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634. 
  4. ^ Costa L, Trovato C, Musumeci SA, Catania MV, Ciranna L (April 2011). "5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission". Hippocampus 22 (4): 790–801. doi:10.1002/hipo.20940. PMID 21538661.