LPAR2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lysophosphatidic acid receptor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LPAR2 ; EDG-4; EDG4; LPA-2; LPA2
External IDs OMIM605110 MGI1858422 HomoloGene3465 IUPHAR: LPA2 ChEMBL: 3724 GeneCards: LPAR2 Gene
RNA expression pattern
PBB GE EDG4 206723 s at tn.png
PBB GE EDG4 206722 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9170 53978
Ensembl ENSG00000064547 ENSMUSG00000031861
UniProt Q9HBW0 E9QJW6
RefSeq (mRNA) NM_004720 NM_020028
RefSeq (protein) NP_004711 NP_064412
Location (UCSC) Chr 19:
19.62 – 19.63 Mb
Chr 8:
69.82 – 69.83 Mb
PubMed search [1] [2]

Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene.[1][2][3] LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]

Function[edit]

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.[1]

Interactions[edit]

LPAR2 has been shown to interact with TRIP6.[5]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2". 
  2. ^ An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886. 
  3. ^ An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. PMID 9804623. 
  4. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. 
  5. ^ Xu, Jun; Lai Yun-Ju; Lin Weei-Chin; Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. (United States) 279 (11): 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMID 14688263. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.